Phosphoric acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-[4-(4-methoxy-benzoylamino)-2-oxo-2H-pyrimidin-1-yl]-tetrahydro-furan-3-yl ester 4-chloro-phenyl ester 2-cyano-ethyl ester

Base Information

• Chemical Name: Phosphoric acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-[4-(4-methoxy-benzoylamino)-2-oxo-2H-pyrimidin-1-yl]-tetrahydro-furan-3-yl ester 4-chloro-phenyl ester 2-cyano-ethyl ester
• CAS No.: 71100-71-5
• Molecular Formula: C₄₇H₄₄ClN₄O₁₁P
• Molecular Weight: 907.313

Synonyms:Phosphoric acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-[4-(4-methoxy-benzoylamino)-2-oxo-2H-pyrimidin-1-yl]-tetrahydro-furan-3-yl ester 4-chloro-phenyl ester 2-cyano-ethyl ester

Chemical Property of Phosphoric acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-[4-(4-methoxy-benzoylamino)-2-oxo-2H-pyrimidin-1-yl]-tetrahydro-furan-3-yl ester 4-chloro-phenyl ester 2-cyano-ethyl ester

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

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Useful:

Technology Process of Phosphoric acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-[4-(4-methoxy-benzoylamino)-2-oxo-2H-pyrimidin-1-yl]-tetrahydro-furan-3-yl ester 4-chloro-phenyl ester 2-cyano-ethyl ester

There total 5 articles about Phosphoric acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-[4-(4-methoxy-benzoylamino)-2-oxo-2H-pyrimidin-1-yl]-tetrahydro-furan-3-yl ester 4-chloro-phenyl ester 2-cyano-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

Phosphorous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-[4-(4-methoxy-benzoylamino)-2-oxo-2H-pyrimidin-1-yl]-tetrahydro-furan-3-yl ester 4-chloro-phenyl ester 2-cyano-ethyl ester → Phosphoric acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-[4-(4-methoxy-benzoylamino)-2-oxo-2H-pyrimidin-1-yl]-tetrahydro-furan-3-yl ester 4-chloro-phenyl ester 2-cyano-ethyl ester (71100-71-5)

Guidance literature:

With iodine; In tetrahydrofuran; water; Ambient temperature;

DOI:10.1016/S0040-4039(00)78985-4

Reference yield:

p-chlorophenyl phosphorodichloridite (32666-92-5) → Phosphoric acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-[4-(4-methoxy-benzoylamino)-2-oxo-2H-pyrimidin-1-yl]-tetrahydro-furan-3-yl ester 4-chloro-phenyl ester 2-cyano-ethyl ester (71100-71-5)

Guidance literature:

Multi-step reaction with 3 steps

1: lutidine-2,6 / tetrahydrofuran / -78 °C

2: lutidine-2,6 / tetrahydrofuran / -20 °C

3: 80 percent / I₂ / tetrahydrofuran; H₂O / Ambient temperature

With 2,6-dimethylpyridine; iodine; In tetrahydrofuran; water;

DOI:10.1016/S0040-4039(00)78985-4

Reference yield:

N4-anisoyl-5'-O-(4,4'-dimethoxytrityl) 2'-deoxy cytidine (68892-40-0) → Phosphoric acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-[4-(4-methoxy-benzoylamino)-2-oxo-2H-pyrimidin-1-yl]-tetrahydro-furan-3-yl ester 4-chloro-phenyl ester 2-cyano-ethyl ester (71100-71-5)

Guidance literature:

Multi-step reaction with 3 steps

1: lutidine-2,6 / tetrahydrofuran / -78 °C

2: lutidine-2,6 / tetrahydrofuran / -20 °C

3: 80 percent / I₂ / tetrahydrofuran; H₂O / Ambient temperature

With 2,6-dimethylpyridine; iodine; In tetrahydrofuran; water;

DOI:10.1016/S0040-4039(00)78985-4

upstream raw materials:

N⁴-anisoyl-5'-O-(4,4'-dimethoxytrityl) 2'-deoxy cytidine

3-Hydroxypropionitrile

4-chlorophenylphosphorodichloridate

p-chlorophenyl phosphorodichloridite

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