(S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(4-(methylthio)-3-(N-(2-morpholinoethyl)methyl-sulfonamido)benzoyloxy)ethyl)pyridine 1-oxide

Base Information

Chemical Name:(S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(4-(methylthio)-3-(N-(2-morpholinoethyl)methyl-sulfonamido)benzoyloxy)ethyl)pyridine 1-oxide
CAS No.:1610862-40-2
Molecular Formula:C₃₃H₃₇Cl₂F₂N₃O₈S₂
Molecular Weight:776.707
Hs Code.:

(S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(4-(methylthio)-3-(N-(2-morpholinoethyl)methyl-sulfonamido)benzoyloxy)ethyl)pyridine 1-oxide

Synonyms:(S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(4-(methylthio)-3-(N-(2-morpholinoethyl)methyl-sulfonamido)benzoyloxy)ethyl)pyridine 1-oxide

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Chemical Property of (S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(4-(methylthio)-3-(N-(2-morpholinoethyl)methyl-sulfonamido)benzoyloxy)ethyl)pyridine 1-oxide

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Technology Process of (S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(4-(methylthio)-3-(N-(2-morpholinoethyl)methyl-sulfonamido)benzoyloxy)ethyl)pyridine 1-oxide

There total 5 articles about (S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(4-(methylthio)-3-(N-(2-morpholinoethyl)methyl-sulfonamido)benzoyloxy)ethyl)pyridine 1-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.3%

: 3240-94-6
N-(2-chlorethyl)morpholine

: 1610862-41-3
(S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)-phenyl)-2-(3-(methylsulfonamido)-4-(methylthio)benzoyloxy)-ethyl)pyridine 1-oxide

: 1610862-40-2
(S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(4-(methylthio)-3-(N-(2-morpholinoethyl)methyl-sulfonamido)benzoyloxy)ethyl)pyridine 1-oxide

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 45 ℃; for 6h;

Reference yield:

: (S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-hydroxyethyl)pyridine 1-oxide

: 1610862-40-2
(S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(4-(methylthio)-3-(N-(2-morpholinoethyl)methyl-sulfonamido)benzoyloxy)ethyl)pyridine 1-oxide

Guidance literature:: Multi-step reaction with 4 steps

1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 20 °C

2: tin(II) chloride dihdyrate / tetrahydrofuran / 20 °C

3: pyridine / dichloromethane / 8 h / 20 °C

4: potassium carbonate / N,N-dimethyl-formamide / 6 h / 45 °C

With pyridine; dmap; tin(II) chloride dihdyrate; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 64399-24-2
3-nitro-4-(methylthio)benzoic acid

: 1610862-40-2
(S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(4-(methylthio)-3-(N-(2-morpholinoethyl)methyl-sulfonamido)benzoyloxy)ethyl)pyridine 1-oxide

Guidance literature:: Multi-step reaction with 4 steps

1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 20 °C

2: tin(II) chloride dihdyrate / tetrahydrofuran / 20 °C

3: pyridine / dichloromethane / 8 h / 20 °C

4: potassium carbonate / N,N-dimethyl-formamide / 6 h / 45 °C

With pyridine; dmap; tin(II) chloride dihdyrate; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;