(R)-5-(benzyloxy)-3-(5-(triisopropylsilyloxy)-1H-indol-2-yl)pentanoic acid

Base Information

Chemical Name:(R)-5-(benzyloxy)-3-(5-(triisopropylsilyloxy)-1H-indol-2-yl)pentanoic acid
CAS No.:1333379-82-0
Molecular Formula:C₂₉H₄₁NO₄Si
Molecular Weight:495.734
Hs Code.:

Synonyms:(R)-5-(benzyloxy)-3-(5-(triisopropylsilyloxy)-1H-indol-2-yl)pentanoic acid

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Chemical Property of (R)-5-(benzyloxy)-3-(5-(triisopropylsilyloxy)-1H-indol-2-yl)pentanoic acid

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Technology Process of (R)-5-(benzyloxy)-3-(5-(triisopropylsilyloxy)-1H-indol-2-yl)pentanoic acid

There total 3 articles about (R)-5-(benzyloxy)-3-(5-(triisopropylsilyloxy)-1H-indol-2-yl)pentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1181215-55-3
tert-butyl (R)-3-((S)-4-benzyl-2-oxo-oxazolidine-3-carbonyl)-5-benzyloxy-pentanoate

: 1333379-82-0
(R)-5-(benzyloxy)-3-(5-(triisopropylsilyloxy)-1H-indol-2-yl)pentanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: dihydrogen peroxide; lithium hydrochloride monohydrate / water; tetrahydrofuran / 0 - 20 °C

1.2: pH 5

2.1: sodium hydrogencarbonate / ISOPROPYLAMIDE / 20 °C

3.1: sec.-butyllithium / cyclohexane; tetrahydrofuran / 1.25 h / -40 °C / Inert atmosphere

3.2: 0.5 h / -78 °C / Inert atmosphere

3.3: -78 °C / Inert atmosphere

With lithium hydrochloride monohydrate; dihydrogen peroxide; sec.-butyllithium; sodium hydrogencarbonate; In tetrahydrofuran; ISOPROPYLAMIDE; cyclohexane; water;

Reference yield:

: 169897-87-4
[4S]-4-benzyl-3-(4-benzyloxy-1-butanoyl)-2-oxazolidinone

: 1333379-82-0
(R)-5-(benzyloxy)-3-(5-(triisopropylsilyloxy)-1H-indol-2-yl)pentanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / -78 - 20 °C

1.2: 20 °C

2.1: dihydrogen peroxide; lithium hydrochloride monohydrate / water; tetrahydrofuran / 0 - 20 °C

2.2: pH 5

3.1: sodium hydrogencarbonate / ISOPROPYLAMIDE / 20 °C

4.1: sec.-butyllithium / cyclohexane; tetrahydrofuran / 1.25 h / -40 °C / Inert atmosphere

4.2: 0.5 h / -78 °C / Inert atmosphere

4.3: -78 °C / Inert atmosphere

With lithium hydrochloride monohydrate; dihydrogen peroxide; sec.-butyllithium; sodium hydrogencarbonate; lithium hexamethyldisilazane; In tetrahydrofuran; ISOPROPYLAMIDE; cyclohexane; water;

Reference yield:

: 1333379-80-8
(R)-2-(2-(benzyloxy)ethyl)-4-tert-butoxy-4-oxobutanoic acid

: 1333379-82-0
(R)-5-(benzyloxy)-3-(5-(triisopropylsilyloxy)-1H-indol-2-yl)pentanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydrogencarbonate / ISOPROPYLAMIDE / 20 °C

2.1: sec.-butyllithium / cyclohexane; tetrahydrofuran / 1.25 h / -40 °C / Inert atmosphere

2.2: 0.5 h / -78 °C / Inert atmosphere

2.3: -78 °C / Inert atmosphere

With sec.-butyllithium; sodium hydrogencarbonate; In tetrahydrofuran; ISOPROPYLAMIDE; cyclohexane;