2-(2-fluoro-4-nitrophenoxy)-N-(2-fluoro-5-(3-methyl-2,6-dioxo-4-(trifluoromethyl)-2,3-dihydropyrimidin-1(6H)-yl)phenyl)propanamide

Base Information

Chemical Name:2-(2-fluoro-4-nitrophenoxy)-N-(2-fluoro-5-(3-methyl-2,6-dioxo-4-(trifluoromethyl)-2,3-dihydropyrimidin-1(6H)-yl)phenyl)propanamide
CAS No.:1048953-56-5
Molecular Formula:C₂₁H₁₅F₅N₄O₆
Molecular Weight:514.365
Hs Code.:

Synonyms:2-(2-fluoro-4-nitrophenoxy)-N-(2-fluoro-5-(3-methyl-2,6-dioxo-4-(trifluoromethyl)-2,3-dihydropyrimidin-1(6H)-yl)phenyl)propanamide

Suppliers and Price of 2-(2-fluoro-4-nitrophenoxy)-N-(2-fluoro-5-(3-methyl-2,6-dioxo-4-(trifluoromethyl)-2,3-dihydropyrimidin-1(6H)-yl)phenyl)propanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(2-fluoro-4-nitrophenoxy)-N-(2-fluoro-5-(3-methyl-2,6-dioxo-4-(trifluoromethyl)-2,3-dihydropyrimidin-1(6H)-yl)phenyl)propanamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 2-(2-fluoro-4-nitrophenoxy)-N-(2-fluoro-5-(3-methyl-2,6-dioxo-4-(trifluoromethyl)-2,3-dihydropyrimidin-1(6H)-yl)phenyl)propanamide

There total 6 articles about 2-(2-fluoro-4-nitrophenoxy)-N-(2-fluoro-5-(3-methyl-2,6-dioxo-4-(trifluoromethyl)-2,3-dihydropyrimidin-1(6H)-yl)phenyl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1357510-37-2
C₉H₇ClFNO₄

: 1048953-79-2
3-(3-amino-4-fluorophenyl)-1-methyl-6-(trifluoromethyl)pyrimidine-2,4(1H,3H)-dione

: 1048953-56-5
2-(2-fluoro-4-nitrophenoxy)-N-(2-fluoro-5-(3-methyl-2,6-dioxo-4-(trifluoromethyl)-2,3-dihydropyrimidin-1(6H)-yl)phenyl)propanamide

Guidance literature:: With triethylamine; In toluene; at 0 - 20 ℃;
DOI:10.1002/cjoc.201180410

Reference yield:

: 1357510-83-8
3-(4-fluorophenyl-3-nitrophenyl)-1-methyl-6-(trifluoromethyl)pyrimidine-2,4(1H,3H)-dione

: 1048953-56-5
2-(2-fluoro-4-nitrophenoxy)-N-(2-fluoro-5-(3-methyl-2,6-dioxo-4-(trifluoromethyl)-2,3-dihydropyrimidin-1(6H)-yl)phenyl)propanamide

Guidance literature:: Multi-step reaction with 2 steps

1: iron; acetic acid

2: triethylamine / toluene / 0 - 20 °C

With iron; acetic acid; triethylamine; In toluene;
DOI:10.1002/cjoc.201180410

Reference yield:

: 50844-60-5
3-(4-fluorophenyl)-6-(trifluoromethyl)pyrimidine-2,4-(1H,3H)-dione

: 1048953-56-5
2-(2-fluoro-4-nitrophenoxy)-N-(2-fluoro-5-(3-methyl-2,6-dioxo-4-(trifluoromethyl)-2,3-dihydropyrimidin-1(6H)-yl)phenyl)propanamide

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide

2: sulfuric acid; nitric acid

3: iron; acetic acid

4: triethylamine / toluene / 0 - 20 °C

With sulfuric acid; nitric acid; iron; potassium carbonate; acetic acid; triethylamine; In N,N-dimethyl-formamide; toluene;
DOI:10.1002/cjoc.201180410