1-(2-bromoethyl)-2-(bromomethyl)-4-methylbenzene

Base Information

• Chemical Name: 1-(2-bromoethyl)-2-(bromomethyl)-4-methylbenzene
• CAS No.: 112625-35-1
• Molecular Formula: C₁₀H₁₂Br₂
• Molecular Weight: 292.013
• Mol file: 112625-35-1.mol

Synonyms:1-(2-bromoethyl)-2-(bromomethyl)-4-methylbenzene

Chemical Property of 1-(2-bromoethyl)-2-(bromomethyl)-4-methylbenzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(2-bromoethyl)-2-(bromomethyl)-4-methylbenzene

There total 2 articles about 1-(2-bromoethyl)-2-(bromomethyl)-4-methylbenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

3,4-dihydro-7-methyl-1H-isochromene (103261-92-3) → 1-(2-bromoethyl)-2-(bromomethyl)-4-methylbenzene (112625-35-1)

Guidance literature:

With hydrogen bromide; In acetic acid; at 110 ℃; for 18h;

DOI:10.1021/jm200862h

Reference yield:

4-Methylphenethyl alcohol (699-02-5) → 1-(2-bromoethyl)-2-(bromomethyl)-4-methylbenzene (112625-35-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 2.5 h / 20 °C / Inert atmosphere

1.2: Inert atmosphere

2.1: titanium tetrachloride / dichloromethane / 2.5 h / 0 °C / Inert atmosphere

3.1: hydrogen bromide / acetic acid / 18 h / 110 °C

With hydrogen bromide; titanium tetrachloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; acetic acid;

DOI:10.1021/jm200862h

Reference yield: 65.0%

1-(2-bromoethyl)-2-(bromomethyl)-4-methylbenzene (112625-35-1) + 2-acetylaminomalonic acid diethyl ester (1068-90-2) → diethyl 2-acetamido-2-(2-(2-bromoethyl)-5-methylbenzyl)malonate (149911-07-9)

Guidance literature:

2-acetylaminomalonic acid diethyl ester; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 5 ℃; for 0.5h; Inert atmosphere;

1-(2-bromoethyl)-2-(bromomethyl)-4-methylbenzene; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 16h; Inert atmosphere;

DOI:10.1021/jm200862h

upstream raw materials:

3,4-dihydro-7-methyl-1H-isochromene

4-Methylphenethyl alcohol

Downstream raw materials:

1-(2-acetoxy-ethyl)-2-acetoxymethyl-4-methyl-benzene

2-hydroxymethyl-4-methyl-phenethyl alcohol

diethyl 2-acetamido-2-(2-(2-cyanoethyl)-5-methylbenzyl)malonate

diethyl 2-acetamido-2-(5-(bromomethyl)-2-(2-cyanoethyl)benzyl)malonate