(R)-3-(4-chlorophenylsulfanyl)-2-isobutyrylamino-2-methylpropionic acid methyl ester

Base Information

Chemical Name:(R)-3-(4-chlorophenylsulfanyl)-2-isobutyrylamino-2-methylpropionic acid methyl ester
CAS No.:519021-04-6
Molecular Formula:C₁₅H₂₀ClNO₃S
Molecular Weight:329.848
Hs Code.:

Synonyms:(R)-3-(4-chlorophenylsulfanyl)-2-isobutyrylamino-2-methylpropionic acid methyl ester

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Chemical Property of (R)-3-(4-chlorophenylsulfanyl)-2-isobutyrylamino-2-methylpropionic acid methyl ester

Chemical Property:

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Technology Process of (R)-3-(4-chlorophenylsulfanyl)-2-isobutyrylamino-2-methylpropionic acid methyl ester

There total 4 articles about (R)-3-(4-chlorophenylsulfanyl)-2-isobutyrylamino-2-methylpropionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 79-30-1
isobutyryl chloride

: (R)-2-Amino-3-(4-chloro-phenylsulfanyl)-2-methyl-propionic acid methyl ester; hydrobromide

: 519021-04-6
(R)-3-(4-chlorophenylsulfanyl)-2-isobutyrylamino-2-methylpropionic acid methyl ester

Guidance literature:: With dmap; N-ethyl-N,N-diisopropylamine; In dichloromethane; at -78 ℃;

Reference yield:

: 102618-23-5
iodomethyl 4-chlorophenyl sulfide

: 519021-04-6
(R)-3-(4-chlorophenylsulfanyl)-2-isobutyrylamino-2-methylpropionic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 69 percent / DMPU; LHMDS / tetrahydrofuran / -78 °C

2: 85 percent / NaOMe; MeOH / tetrahydrofuran / 0 °C

3: HBr; AcOH / CH₂Cl₂ / 20 °C

4: DIPEA; DMAP / CH₂Cl₂ / -78 °C

With methanol; dmap; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; hydrogen bromide; sodium methylate; acetic acid; N-ethyl-N,N-diisopropylamine; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane;

Reference yield:

: 519021-06-8
(R)-2-benzyloxycarbonylamino-3-(4-chlorophenylsulfanyl)-2-methylpropionic acid methyl ester

: 519021-04-6
(R)-3-(4-chlorophenylsulfanyl)-2-isobutyrylamino-2-methylpropionic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: HBr; AcOH / CH₂Cl₂ / 20 °C

2: DIPEA; DMAP / CH₂Cl₂ / -78 °C

With dmap; hydrogen bromide; acetic acid; N-ethyl-N,N-diisopropylamine; In dichloromethane;