1,2,3,4-tetrahydro-4-oxo-9-<(p-methoxyphenyl)sulfonyl>carbazole-2-acetic acid

Base Information

Chemical Name:1,2,3,4-tetrahydro-4-oxo-9-<(p-methoxyphenyl)sulfonyl>carbazole-2-acetic acid
CAS No.:137333-40-5
Molecular Formula:C₂₁H₁₉NO₆S
Molecular Weight:413.451
Hs Code.:

Synonyms:1,2,3,4-tetrahydro-4-oxo-9-<(p-methoxyphenyl)sulfonyl>carbazole-2-acetic acid

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Chemical Property of 1,2,3,4-tetrahydro-4-oxo-9-<(p-methoxyphenyl)sulfonyl>carbazole-2-acetic acid

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Technology Process of 1,2,3,4-tetrahydro-4-oxo-9-<(p-methoxyphenyl)sulfonyl>carbazole-2-acetic acid

There total 6 articles about 1,2,3,4-tetrahydro-4-oxo-9-<(p-methoxyphenyl)sulfonyl>carbazole-2-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 137333-39-2
[9-(4-Methoxy-benzenesulfonyl)-4-oxo-2,3,4,9-tetrahydro-1H-carbazol-2-yl]-acetic acid methyl ester

: 137333-40-5
1,2,3,4-tetrahydro-4-oxo-9-<(p-methoxyphenyl)sulfonyl>carbazole-2-acetic acid

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; at 23 ℃; for 1h; Yield given;
DOI:10.1021/jo00027a016

Reference yield:

: 137333-34-7,137333-35-8,39762-51-1
(3-Oxo-cyclohexyl)-acetic Acid

: 137333-40-5
1,2,3,4-tetrahydro-4-oxo-9-<(p-methoxyphenyl)sulfonyl>carbazole-2-acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 73 percent / aq. acetic acid / 10 h / Heating

2: 99.6 percent / concd HCl, dimethoxypropane / 2 h / 20 °C

3: 85 percent / dichlorodicyanoquinone / tetrahydrofuran; H₂O / 2 h / 0 °C

4: tetra-N-benzylammonium chloride, 30percent NaOH / CH₂Cl₂ / 1 h

5: aq. lithium hydroxide / tetrahydrofuran / 1 h / 23 °C

With hydrogenchloride; lithium hydroxide; sodium hydroxide; Bn₄NCl; dimethoxypropane; acetic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; dichloromethane; water;
DOI:10.1021/jo00027a016

Reference yield:

: 59-88-1
phenylhydrazine hydrochloride

: 137333-40-5
1,2,3,4-tetrahydro-4-oxo-9-<(p-methoxyphenyl)sulfonyl>carbazole-2-acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 73 percent / aq. acetic acid / 10 h / Heating

2: 99.6 percent / concd HCl, dimethoxypropane / 2 h / 20 °C

3: 85 percent / dichlorodicyanoquinone / tetrahydrofuran; H₂O / 2 h / 0 °C

4: tetra-N-benzylammonium chloride, 30percent NaOH / CH₂Cl₂ / 1 h

5: aq. lithium hydroxide / tetrahydrofuran / 1 h / 23 °C

With hydrogenchloride; lithium hydroxide; sodium hydroxide; Bn₄NCl; dimethoxypropane; acetic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; dichloromethane; water;
DOI:10.1021/jo00027a016