3-(3-(5-aminopyrazin-2-yl)-4-chlorophenyl)-5,5-dimethylisoxazol-4(5H)-one

Base Information

Chemical Name:3-(3-(5-aminopyrazin-2-yl)-4-chlorophenyl)-5,5-dimethylisoxazol-4(5H)-one
CAS No.:1373939-92-4
Molecular Formula:C₁₅H₁₃ClN₄O₂
Molecular Weight:316.747
Hs Code.:

Synonyms:3-(3-(5-aminopyrazin-2-yl)-4-chlorophenyl)-5,5-dimethylisoxazol-4(5H)-one

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Chemical Property of 3-(3-(5-aminopyrazin-2-yl)-4-chlorophenyl)-5,5-dimethylisoxazol-4(5H)-one

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Technology Process of 3-(3-(5-aminopyrazin-2-yl)-4-chlorophenyl)-5,5-dimethylisoxazol-4(5H)-one

There total 7 articles about 3-(3-(5-aminopyrazin-2-yl)-4-chlorophenyl)-5,5-dimethylisoxazol-4(5H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 321957-61-3
5-(trimethylstannyl)pyrazine-2-amine

: 3-(3-bromo-4-chlorophenyl)-5,5-dimethylisoxazol-4(5H)-one

: 1373939-92-4
3-(3-(5-aminopyrazin-2-yl)-4-chlorophenyl)-5,5-dimethylisoxazol-4(5H)-one

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; at 110 ℃; for 12h; Inert atmosphere;
DOI:10.1021/acs.jmedchem.1c01403

Reference yield:

: 321957-61-3
5-(trimethylstannyl)pyrazine-2-amine

: 1373939-90-2
3-(3-bromo-4-(tert-butyl)phenyl)-5,5-dimethylisoxazol-4(5H)-one

: 1373939-92-4
3-(3-(5-aminopyrazin-2-yl)-4-chlorophenyl)-5,5-dimethylisoxazol-4(5H)-one

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; at 110 ℃; for 12h; Inert atmosphere;
DOI:10.1021/acs.jmedchem.1c01403

Reference yield:

: 42860-10-6
3-bromo-4-chlorobenzoic acid

: 1373939-92-4
3-(3-(5-aminopyrazin-2-yl)-4-chlorophenyl)-5,5-dimethylisoxazol-4(5H)-one

Guidance literature:: Multi-step reaction with 6 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / dichloromethane / 16 h / 20 °C

2: tetrahydrofuran / 2 h / -20 - 20 °C

3: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 12 h / 0 - 20 °C

4: pyridine; hydroxylamine hydrochloride / methanol / 12 h / Reflux

5: acetic acid; chromium(VI) oxide; sulfuric acid / water / 0.5 h / 100 °C

6: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 12 h / 110 °C / Inert atmosphere

With pyridine; chromium(VI) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sulfuric acid; hydroxylamine hydrochloride; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water;
DOI:10.1021/acs.jmedchem.1c01403