C₂₇H₂₈N₂O₈

Base Information

• Chemical Name: C₂₇H₂₈N₂O₈
• CAS No.: 1315454-85-3
• Molecular Formula: C₂₇H₂₈N₂O₈
• Molecular Weight: 508.528
• Mol file: 1315454-85-3.mol

Synonyms:C₂₇H₂₈N₂O₈

Chemical Property of C₂₇H₂₈N₂O₈

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₇H₂₈N₂O₈

There total 20 articles about C₂₇H₂₈N₂O₈ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

bis(trichloromethyl) carbonate (32315-10-9) + C26H30N2O7 → C27H28N2O8 (1315455-24-3) + C27H28N2O8 (1315454-85-3)

Guidance literature:

With pyridine; In dichloromethane; at -78 - 0 ℃; for 0.166667h; Inert atmosphere;

DOI:10.1002/chem.201003489

Reference yield:

3-benzyloxy-4-iodo-5-nitrobenzaldehyde (1016976-13-8) → C27H28N2O8 (1315455-24-3) + C27H28N2O8 (1315454-85-3)

Guidance literature:

Multi-step reaction with 9 steps

1: N-iodo-succinimide; potassium carbonate / acetonitrile / 12 h / 5 °C / Inert atmosphere; Darkness

2: iron; acetic acid / tetrahydrofuran; methanol / 3.5 h / 20 °C / Inert atmosphere

3: acetic acid / chloroform / 12 h / 20 °C / Molecular sieve; Inert atmosphere

4: sodium cyanoborohydride / tetrahydrofuran / 2 h / Inert atmosphere

5: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 0 °C / Inert atmosphere

6: pyridine; trifluoroacetic anhydride / dichloromethane / 12 h / -78 °C / Inert atmosphere

7: palladium diacetate; triphenylphosphine; silver carbonate / 1,4-dioxane / 1 h / 80 °C / Inert atmosphere

8: 4-methyl-morpholine; osmium(VIII) oxide / tetrahydrofuran; water; acetone / 5 h / 20 °C / Inert atmosphere

9: pyridine / dichloromethane / 0.17 h / -78 - 0 °C / Inert atmosphere

With 4-methyl-morpholine; pyridine; N-iodo-succinimide; osmium(VIII) oxide; tetrabutyl ammonium fluoride; palladium diacetate; iron; sodium cyanoborohydride; potassium carbonate; acetic acid; triphenylphosphine; silver carbonate; trifluoroacetic anhydride; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; chloroform; water; acetone; acetonitrile; 7: Heck reaction / 9: Polonovski reaction;

DOI:10.1002/chem.201003489

Reference yield:

methyl 3-amino-5-benzyloxy-4-iodobenzoate (1016976-14-9) → C27H28N2O8 (1315455-24-3) + C27H28N2O8 (1315454-85-3)

Guidance literature:

Multi-step reaction with 7 steps

1: acetic acid / chloroform / 12 h / 20 °C / Molecular sieve; Inert atmosphere

2: sodium cyanoborohydride / tetrahydrofuran / 2 h / Inert atmosphere

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 0 °C / Inert atmosphere

4: pyridine; trifluoroacetic anhydride / dichloromethane / 12 h / -78 °C / Inert atmosphere

5: palladium diacetate; triphenylphosphine; silver carbonate / 1,4-dioxane / 1 h / 80 °C / Inert atmosphere

6: 4-methyl-morpholine; osmium(VIII) oxide / tetrahydrofuran; water; acetone / 5 h / 20 °C / Inert atmosphere

7: pyridine / dichloromethane / 0.17 h / -78 - 0 °C / Inert atmosphere

With 4-methyl-morpholine; pyridine; osmium(VIII) oxide; tetrabutyl ammonium fluoride; palladium diacetate; sodium cyanoborohydride; acetic acid; triphenylphosphine; silver carbonate; trifluoroacetic anhydride; In tetrahydrofuran; 1,4-dioxane; dichloromethane; chloroform; water; acetone; 5: Heck reaction / 7: Polonovski reaction;

DOI:10.1002/chem.201003489

upstream raw materials:

3-benzyloxy-4-iodo-5-nitrobenzaldehyde

methyl 3-amino-5-benzyloxy-4-iodobenzoate

C₂₀H₂₇NO₃Si

C₂₀H₂₉NO₅Si

Downstream raw materials:

C₂₇H₂₈N₂O₉

C₂₇H₂₈N₂O₁₀

C₂₇H₂₈N₂O₁₀