6-(3-METHOXYPHENYL)-2-OXO-1,2-DIHYDRO-3-PYRIDINECARBONITRILE

Base Information

• Chemical Name: 6-(3-METHOXYPHENYL)-2-OXO-1,2-DIHYDRO-3-PYRIDINECARBONITRILE
• CAS No.: 142499-40-9
• Molecular Formula: C₁₃H₁₀N₂O₂
• Molecular Weight: 226.235
• Mol file: 142499-40-9.mol

Synonyms:6-(3-methoxy-phenyl)-2-oxo-1,2-dihydro-pyridine-3-carbonitrile

Chemical Property of 6-(3-METHOXYPHENYL)-2-OXO-1,2-DIHYDRO-3-PYRIDINECARBONITRILE

Chemical Property:

• Boiling Point: 476.9±45.0 °C(Predicted)
• PKA: 7.83±0.10(Predicted)
• Density: 1.27±0.1 g/cm3(Predicted)

Purity/Quality:

6-(3-Methoxyphenyl)-2-oxo-1,2-dihydro-3-pyridinecarbonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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Technology Process of 6-(3-METHOXYPHENYL)-2-OXO-1,2-DIHYDRO-3-PYRIDINECARBONITRILE

There total 4 articles about 6-(3-METHOXYPHENYL)-2-OXO-1,2-DIHYDRO-3-PYRIDINECARBONITRILE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

C12H15NO2 (916989-85-0) + cyanoacetic acid amide (107-91-5) → 6-(3-methoxy-phenyl)-2-oxo-1,2-dihydro-pyridine-3-carbonitrile (142499-40-9)

Guidance literature:

C₁₂H₁₅NO₂; cyanoacetic acid amide; With sodium hydride; In N,N-dimethyl-formamide; at 105 ℃; for 2h;

With acetic acid; In water; at 70 ℃; for 0.25h;

Reference yield:

3-(dimethylamino)-1-(3-methoxyphenyl)prop-2-en-1-one (58316-11-3,62041-46-7) + cyanoacetic acid amide (107-91-5) → 6-(3-methoxy-phenyl)-2-oxo-1,2-dihydro-pyridine-3-carbonitrile (142499-40-9)

Guidance literature:

With sodium methylate; In acetonitrile; at 80 ℃;

DOI:10.1016/S0960-894X(03)00645-0

Reference yield:

1-(3-Methoxyphenyl)ethanone (586-37-8) → 6-(3-methoxy-phenyl)-2-oxo-1,2-dihydro-pyridine-3-carbonitrile (142499-40-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 12 h / Heating

2: NaOMe / acetonitrile / 80 °C

With sodium methylate; In acetonitrile;

DOI:10.1016/S0960-894X(03)00645-0

upstream raw materials:

3-(dimethylamino)-1-(3-methoxyphenyl)prop-2-en-1-one

cyanoacetic acid amide

1-(3-Methoxyphenyl)ethanone

C₁₂H₁₅NO₂

Downstream raw materials:

2-chloro-6-(3-methoxy-phenyl)-nicotinonitrile

6-(3-methoxy-phenyl)-1H-pyrazolo[3,4-b]pyridin-3-ylamine

C₁₆H₁₄N₂O₂

C₁₆H₁₄N₂O₂

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