(-)-(4S,6R)-benzyl 4-(tert-butoxycarbonyl)amino-5-oxo-8-phenyl-6-[(pyrrolidine-1-carbonothioyl)oxy]octanoate

Base Information

Chemical Name:(-)-(4S,6R)-benzyl 4-(tert-butoxycarbonyl)amino-5-oxo-8-phenyl-6-[(pyrrolidine-1-carbonothioyl)oxy]octanoate
CAS No.:1312025-97-0
Molecular Formula:C₃₁H₄₀N₂O₆S
Molecular Weight:568.734
Hs Code.:

Synonyms:(-)-(4S,6R)-benzyl 4-(tert-butoxycarbonyl)amino-5-oxo-8-phenyl-6-[(pyrrolidine-1-carbonothioyl)oxy]octanoate

Suppliers and Price of (-)-(4S,6R)-benzyl 4-(tert-butoxycarbonyl)amino-5-oxo-8-phenyl-6-[(pyrrolidine-1-carbonothioyl)oxy]octanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (-)-(4S,6R)-benzyl 4-(tert-butoxycarbonyl)amino-5-oxo-8-phenyl-6-[(pyrrolidine-1-carbonothioyl)oxy]octanoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (-)-(4S,6R)-benzyl 4-(tert-butoxycarbonyl)amino-5-oxo-8-phenyl-6-[(pyrrolidine-1-carbonothioyl)oxy]octanoate

There total 2 articles about (-)-(4S,6R)-benzyl 4-(tert-butoxycarbonyl)amino-5-oxo-8-phenyl-6-[(pyrrolidine-1-carbonothioyl)oxy]octanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 169140-88-9,1071508-50-3,1071508-47-8
(+)-(S)-O-3-phenyl-1-(tri-n-butylstannyl)propyl pyrrolidine-1-carbothioate

: 1312025-86-7
(-)-(S)-benzyl 4-(tert-butoxycarbonyl)amino-5-(4-nitrophenyl)thio-5-oxopentanoate

: 1312025-97-0
(-)-(4S,6R)-benzyl 4-(tert-butoxycarbonyl)amino-5-oxo-8-phenyl-6-[(pyrrolidine-1-carbonothioyl)oxy]octanoate

Guidance literature:: With copper(I) thiophene-2-carboxylate; In 1,4-dioxane; at 100 ℃; for 20h; Inert atmosphere;
DOI:10.1021/ol201330j

Reference yield:

: 13574-13-5
Boc-Glu(OBzl)-OH

: 1312025-97-0
(-)-(4S,6R)-benzyl 4-(tert-butoxycarbonyl)amino-5-oxo-8-phenyl-6-[(pyrrolidine-1-carbonothioyl)oxy]octanoate

Guidance literature:: Multi-step reaction with 2 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 24.25 h / 0 - 20 °C

2: copper(I) thiophene-2-carboxylate / 1,4-dioxane / 20 h / 100 °C / Inert atmosphere

With copper(I) thiophene-2-carboxylate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane; dichloromethane;
DOI:10.1021/ol201330j