Chemical Property of 2'-DEOXYGUANOSINE
Chemical Property:
- Melting Point:300oC
- Boiling Point:801.4oC at 760 mmHg
- PKA:pK1:2.5(+1) (25°C,μ=0.1)
- Flash Point:438.5oC
- PSA：139.28000
- LogP:-1.07630
- Storage Temp.:Refrigerator
- Solubility.:NH4OH 1 M: 50 mg/mL, clear to very faintly turbid, yellow t
- Purity/Quality:
-
99%, *data from raw suppliers
2′-Deoxyguanosine monohydrate
*data from reagent suppliers
Safty Information:
- Pictogram(s):
Xn,T
- Hazard Codes:Xn,T
- Statements:
22-25
- Safety Statements:
45
- MSDS Files:
-
SDS file from LookChem
Useful:
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Description
2''-Deoxyguanosine is a purine nucleoside with diverse biological activities. It inhibits the clonogenic growth of HL-60 and K562 leukemia cells (IC50s = 80 and 100 μM, respectively). 2''-Deoxyguanosine inhibits the growth of MOLT-4 T cells and MGL-8 B cells by 99.8 and 68.3%, respectively, when used at a concentration of 50 μM. It increases the number of binucleated cells, a marker of inhibited cytokinesis, in A. sativum meristems. 2''-Deoxyguanosine (>1 μM) also induces relaxation of precontracted isolated bovine lingual artery.
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Uses
2′-Deoxyguanosine monohydrate has been used in stromal cell purification. It has also been used for the quantification of whole cell dNTP (deoxyribonucleotide triphosphate).
