N-p{N-[3,4-dihydro-4-oxo-2-(pyrimidin-2-ylthiomethyl)quinazolin-6-ylmethyl]-N-(prop-2ynyl)amino}benzoyl-L-glutamic acid

Base Information

Chemical Name:N-p{N-[3,4-dihydro-4-oxo-2-(pyrimidin-2-ylthiomethyl)quinazolin-6-ylmethyl]-N-(prop-2ynyl)amino}benzoyl-L-glutamic acid
CAS No.:112888-25-2
Molecular Formula:C₂₉H₂₆N₆O₆S
Molecular Weight:586.628
Hs Code.:

Synonyms:N-p{N-[3,4-dihydro-4-oxo-2-(pyrimidin-2-ylthiomethyl)quinazolin-6-ylmethyl]-N-(prop-2ynyl)amino}benzoyl-L-glutamic acid

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Chemical Property of N-p{N-[3,4-dihydro-4-oxo-2-(pyrimidin-2-ylthiomethyl)quinazolin-6-ylmethyl]-N-(prop-2ynyl)amino}benzoyl-L-glutamic acid

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Technology Process of N-p{N-[3,4-dihydro-4-oxo-2-(pyrimidin-2-ylthiomethyl)quinazolin-6-ylmethyl]-N-(prop-2ynyl)amino}benzoyl-L-glutamic acid

There total 5 articles about N-p{N-[3,4-dihydro-4-oxo-2-(pyrimidin-2-ylthiomethyl)quinazolin-6-ylmethyl]-N-(prop-2ynyl)amino}benzoyl-L-glutamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 130379-78-1
(S)-2-(4-{[4-Oxo-2-(pyrimidin-2-ylsulfanylmethyl)-3,4-dihydro-quinazolin-6-ylmethyl]-prop-2-ynyl-amino}-benzoylamino)-pentanedioic acid diethyl ester

: 112888-25-2
N-p{N-[3,4-dihydro-4-oxo-2-(pyrimidin-2-ylthiomethyl)quinazolin-6-ylmethyl]-N-(prop-2ynyl)amino}benzoyl-L-glutamic acid

Guidance literature:: With sodium hydroxide; In ethanol; for 2h; Ambient temperature;
DOI:10.1021/jm00173a024

Reference yield:

: 18731-18-5
2-(chloromethyl)-3,4-dihydro-6-methyl-4-oxoquinazoline

: 112888-25-2
N-p{N-[3,4-dihydro-4-oxo-2-(pyrimidin-2-ylthiomethyl)quinazolin-6-ylmethyl]-N-(prop-2ynyl)amino}benzoyl-L-glutamic acid

Guidance literature:: Multi-step reaction with 4 steps

1: N-bromosuccinimide (NBS), benzoyl peroxide / CCl₄ / 8 h / Heating; Irradiation

2: 53 percent / 2,6-lutidine / dimethylformamide / 18 h / 80 °C

3: 1.) 50percent NaH in oil / 1.) DMF, RT, 30 min, 2.) 17 h

4: 87 percent / 1 N aq. NaOH / ethanol / 2 h / Ambient temperature

With 2,6-dimethylpyridine; sodium hydroxide; N-Bromosuccinimide; Perbenzoic acid; sodium hydride; In tetrachloromethane; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00173a024

Reference yield:

: 112888-85-4
6-(bromomethyl)-2-(chloromethyl)-3,4-dihydro-4-oxoquinazoline

: 112888-25-2
N-p{N-[3,4-dihydro-4-oxo-2-(pyrimidin-2-ylthiomethyl)quinazolin-6-ylmethyl]-N-(prop-2ynyl)amino}benzoyl-L-glutamic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 53 percent / 2,6-lutidine / dimethylformamide / 18 h / 80 °C

2: 1.) 50percent NaH in oil / 1.) DMF, RT, 30 min, 2.) 17 h

3: 87 percent / 1 N aq. NaOH / ethanol / 2 h / Ambient temperature

With 2,6-dimethylpyridine; sodium hydroxide; sodium hydride; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00173a024