methyl (S)-2-(N-(tert-butoxycarbonyl)-4-methylphenylsulfonamido)-5-hydroxy-7-(trimethylsilyl)hept-6-ynoate

Base Information

Chemical Name:methyl (S)-2-(N-(tert-butoxycarbonyl)-4-methylphenylsulfonamido)-5-hydroxy-7-(trimethylsilyl)hept-6-ynoate
CAS No.:1034187-57-9
Molecular Formula:C₂₃H₃₅NO₇SSi
Molecular Weight:497.685
Hs Code.:

Synonyms:methyl (S)-2-(N-(tert-butoxycarbonyl)-4-methylphenylsulfonamido)-5-hydroxy-7-(trimethylsilyl)hept-6-ynoate

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Chemical Property of methyl (S)-2-(N-(tert-butoxycarbonyl)-4-methylphenylsulfonamido)-5-hydroxy-7-(trimethylsilyl)hept-6-ynoate

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Technology Process of methyl (S)-2-(N-(tert-butoxycarbonyl)-4-methylphenylsulfonamido)-5-hydroxy-7-(trimethylsilyl)hept-6-ynoate

There total 1 articles about methyl (S)-2-(N-(tert-butoxycarbonyl)-4-methylphenylsulfonamido)-5-hydroxy-7-(trimethylsilyl)hept-6-ynoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1034187-58-0
methyl (S)-2-(N-(tert-butoxycarbonyl)-4-methylphenylsulfonamido)-5-oxopentanoate

: 1066-54-2
trimethylsilylacetylene

: 1034187-57-9
methyl (S)-2-(N-(tert-butoxycarbonyl)-4-methylphenylsulfonamido)-5-hydroxy-7-(trimethylsilyl)hept-6-ynoate

Guidance literature:: trimethylsilylacetylene; With n-butyllithium; In tetrahydrofuran; hexane; at -78 - 20 ℃;

methyl (S)-2-(N-(tert-butoxycarbonyl)-4-methylphenylsulfonamido)-5-oxopentanoate; In tetrahydrofuran; hexane; at -100 - -65 ℃;
DOI:10.1021/ol800544a

Reference yield: 94.0%

: 1034187-57-9
methyl (S)-2-(N-(tert-butoxycarbonyl)-4-methylphenylsulfonamido)-5-hydroxy-7-(trimethylsilyl)hept-6-ynoate

: 1034187-59-1
methyl (S)-5-hydroxy-2-(4-methylphenylsulfonamido)-7-(trimethylsilyl)hept-6-ynoate

Guidance literature:: With lithium bromide; In acetonitrile; at 65 ℃; for 6h;
DOI:10.1021/ol800544a

Reference yield:

: 1034187-57-9
methyl (S)-2-(N-(tert-butoxycarbonyl)-4-methylphenylsulfonamido)-5-hydroxy-7-(trimethylsilyl)hept-6-ynoate

: 1034187-71-7
methyl (2S,5R)-1-tosyl-5-((trimethylsilyl)ethynyl)pyrrolidine-2-carboxylate

Guidance literature:: methyl (S)-2-(N-(tert-butoxycarbonyl)-4-methylphenylsulfonamido)-5-hydroxy-7-(trimethylsilyl)hept-6-ynoate; With dicobalt octacarbonyl; In dichloromethane; at 20 ℃; for 12h; Inert atmosphere;

With boron trifluoride diethyl etherate; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1021/ol800544a