4-Ethoxy-2-hydroxybenzophenone

Base Information

• Chemical Name: 4-Ethoxy-2-hydroxybenzophenone
• CAS No.: 15889-70-0
• Molecular Formula: C15H14O3
• Molecular Weight: 242.27
• Hs Code.: 2914509090
• European Community (EC) Number: 621-142-5
• DSSTox Substance ID: DTXSID70407820
• Nikkaji Number: J1.145.553K
• Wikidata: Q82213161
• Mol file: 15889-70-0.mol

Synonyms:4-Ethoxy-2-hydroxybenzophenone;15889-70-0;(4-ethoxy-2-hydroxyphenyl)-phenylmethanone;4-ETHOXY-2-HYDROXYBENZOPHENONE 97;2-hydroxy-4-ethoxybenzophenone;(4-ethoxy-2-hydroxyphenyl)(phenyl)methanone;SCHEMBL561937;2-hydroxy-4-ethoxy-benzophenone;DTXSID70407820;4-Ethoxy-2-hydroxybenzophenone, 97%;AKOS015910219;J-009539

Chemical Property of 4-Ethoxy-2-hydroxybenzophenone

Chemical Property:

• Melting Point: 54-58 °C(lit.)
• Boiling Point: 382.6 °C at 760 mmHg
• PKA: 7.60±0.35(Predicted)
• Flash Point: 142.3 °C
• PSA: 46.53000
• Density: 1.173±0.06 g/cm3(Predicted)
• LogP: 3.02190
• XLogP3: 4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 242.094294304
• Heavy Atom Count: 18
• Complexity: 271

Purity/Quality:

98%Min ^*data from raw suppliers

4-ETHOXY-2-HYDROXYBENZOPHENONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC1=CC(=C(C=C1)C(=O)C2=CC=CC=C2)O

Technology Process of 4-Ethoxy-2-hydroxybenzophenone

There total 1 articles about 4-Ethoxy-2-hydroxybenzophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ (4-ethoxy-2-hydroxyphenyl)phenyl methanone (15889-70-0)

Guidance literature:

Resorcin, Benzotrichlorid, Aethoxy-p-toluolsulfonat;

Reference yield: 74.0%

(4-ethoxy-2-hydroxyphenyl)phenyl methanone (15889-70-0) + p-toluenesulfonyl chloride (98-59-9) → 2-benzoyl-5-ethoxyphenyl 4-methylbenzenesulfonate (878555-09-0)

Guidance literature:

With pyridine; at 0 - 20 ℃;

DOI:10.1021/ol0529142

Reference yield:

(4-ethoxy-2-hydroxyphenyl)phenyl methanone (15889-70-0) → 2'-benzoyl-5'-ethoxy-[1,1'-biphenyl]-4-carbonitrile

Guidance literature:

Multi-step reaction with 2 steps

1.1: 74 percent / pyridine / 0 - 20 °C

2.1: i-PrMgCl*LiCl / tetrahydrofuran / -20 - 0 °C

2.2: CuCN*2LiCl / tetrahydrofuran / -20 °C

2.3: 78 percent / DMPU; 4-fluorostyrene; Bu₄NI / Co(acac)2 / tetrahydrofuran; 1,2-dimethoxy-ethane / 0.25 h / 25 °C

With pyridine; TurboGrignard; In tetrahydrofuran;

DOI:10.1021/ol0529142

Downstream raw materials:

2-benzoyl-5-ethoxyphenyl 4-methylbenzenesulfonate