(3aS,4R,7S,7aR)-3a,4,7,7a-tetrahydro-7-(methoxymethoxy)-2,2-dimethyl-1,3-benzodioxol-4-ol monobenzoate

Base Information

Chemical Name:(3aS,4R,7S,7aR)-3a,4,7,7a-tetrahydro-7-(methoxymethoxy)-2,2-dimethyl-1,3-benzodioxol-4-ol monobenzoate
CAS No.:438035-01-9
Molecular Formula:C₁₈H₂₂O₆
Molecular Weight:334.369
Hs Code.:

Synonyms:(3aS,4R,7S,7aR)-3a,4,7,7a-tetrahydro-7-(methoxymethoxy)-2,2-dimethyl-1,3-benzodioxol-4-ol monobenzoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3aS,4R,7S,7aR)-3a,4,7,7a-tetrahydro-7-(methoxymethoxy)-2,2-dimethyl-1,3-benzodioxol-4-ol monobenzoate

Chemical Property:

Purity/Quality:

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Hazard Codes:

MSDS Files:: SDS file from LookChem

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Technology Process of (3aS,4R,7S,7aR)-3a,4,7,7a-tetrahydro-7-(methoxymethoxy)-2,2-dimethyl-1,3-benzodioxol-4-ol monobenzoate

There total 9 articles about (3aS,4R,7S,7aR)-3a,4,7,7a-tetrahydro-7-(methoxymethoxy)-2,2-dimethyl-1,3-benzodioxol-4-ol monobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.1%

: 65-85-0,8013-63-6
benzoic acid

: 371155-72-5
(3aS,4S,7S,7aR)-3a,4,7,7a-tetrahydro-7-(methoxymethoxy)-2,2-dimethyl-1,3-benzodioxol-4-ol

: 438035-01-9
(3aS,4R,7S,7aR)-3a,4,7,7a-tetrahydro-7-(methoxymethoxy)-2,2-dimethyl-1,3-benzodioxol-4-ol monobenzoate

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In toluene; at 20 ℃;
DOI:10.1021/jo016237a

Reference yield:

: 219316-93-5
(3aR,4S,7S,7aS)-3a,4,7,7a-tetrahydro-2,2-dimethyl-1,3-benzodioxole-4,7-diol diacetate

: 438035-01-9
(3aS,4R,7S,7aR)-3a,4,7,7a-tetrahydro-7-(methoxymethoxy)-2,2-dimethyl-1,3-benzodioxol-4-ol monobenzoate

Guidance literature:: Multi-step reaction with 5 steps

1: NaOMe / methanol

2: 58.3 percent / pyridine / 5 h / 0 - 10 °C

3: n,N-diisopropylethylamine / CHCl₃ / 20 °C

4: 693 mg / NaOMe / methanol / 3 h / Heating

5: 97.1 percent / PPh₃; DEAD / toluene / 20 °C

With sodium methylate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; diethylazodicarboxylate; In pyridine; methanol; chloroform; toluene; 5: Mitsunobu reaction;
DOI:10.1021/jo016237a

Reference yield:

: 158850-48-7
(3aR,4S,7S,7aS)-3a,4,7,7a-tetrahydro-2,2-dimethyl-1,3-benzodioxole-4,7-diol

: 438035-01-9
(3aS,4R,7S,7aR)-3a,4,7,7a-tetrahydro-7-(methoxymethoxy)-2,2-dimethyl-1,3-benzodioxol-4-ol monobenzoate

Guidance literature:: Multi-step reaction with 4 steps

1: 58.3 percent / pyridine / 5 h / 0 - 10 °C

2: n,N-diisopropylethylamine / CHCl₃ / 20 °C

3: 693 mg / NaOMe / methanol / 3 h / Heating

4: 97.1 percent / PPh₃; DEAD / toluene / 20 °C

With sodium methylate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; diethylazodicarboxylate; In pyridine; methanol; chloroform; toluene; 4: Mitsunobu reaction;
DOI:10.1021/jo016237a