7-methoxynaphthalene-2-sulfonic acid [1-(3-cyanobenzyl)-2-oxopyrrolidin-3-(S)-yl](N-tert-butyloxycarbonylpyrazol-3-ylmethyl)amide

Base Information

Chemical Name:7-methoxynaphthalene-2-sulfonic acid [1-(3-cyanobenzyl)-2-oxopyrrolidin-3-(S)-yl](N-tert-butyloxycarbonylpyrazol-3-ylmethyl)amide
CAS No.:186551-71-3
Molecular Formula:C₃₂H₃₃N₅O₆S
Molecular Weight:615.71
Hs Code.:

Synonyms:7-methoxynaphthalene-2-sulfonic acid [1-(3-cyanobenzyl)-2-oxopyrrolidin-3-(S)-yl](N-tert-butyloxycarbonylpyrazol-3-ylmethyl)amide

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Chemical Property of 7-methoxynaphthalene-2-sulfonic acid [1-(3-cyanobenzyl)-2-oxopyrrolidin-3-(S)-yl](N-tert-butyloxycarbonylpyrazol-3-ylmethyl)amide

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Technology Process of 7-methoxynaphthalene-2-sulfonic acid [1-(3-cyanobenzyl)-2-oxopyrrolidin-3-(S)-yl](N-tert-butyloxycarbonylpyrazol-3-ylmethyl)amide

There total 8 articles about 7-methoxynaphthalene-2-sulfonic acid [1-(3-cyanobenzyl)-2-oxopyrrolidin-3-(S)-yl](N-tert-butyloxycarbonylpyrazol-3-ylmethyl)amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 186551-71-3
7-methoxynaphthalene-2-sulfonic acid [1-(3-cyanobenzyl)-2-oxopyrrolidin-3-(S)-yl](N-tert-butyloxycarbonylpyrazol-3-ylmethyl)amide

Guidance literature:: Multi-step reaction with 3 steps

1: 2.5 g / DMAP / acetonitrile / 2 h / 0 - 20 °C

2: 0.74 g / N-bromosuccinimide; benzoyl peroxide / CCl₄ / 4 h / Heating

3: K₂CO₃ / acetone / 48 h

With dmap; N-Bromosuccinimide; potassium carbonate; dibenzoyl peroxide; In tetrachloromethane; acetone; acetonitrile; 1: amidation / 2: Bromination / 3: Alkylation;
DOI:10.1021/jm990040h

Reference yield:

: 135-55-7
7-hydroxynaphthalene-2-sulfonic acid sodium salt

: 186551-71-3
7-methoxynaphthalene-2-sulfonic acid [1-(3-cyanobenzyl)-2-oxopyrrolidin-3-(S)-yl](N-tert-butyloxycarbonylpyrazol-3-ylmethyl)amide

Guidance literature:: Multi-step reaction with 4 steps

1: aq. NaOH / ethanol / 16 h / 20 °C

2: 3.80 g / POCl₃; PCl₅ / 4 h / 120 °C

3: Et₃N / CH₂Cl₂ / 2 h

4: K₂CO₃ / acetone / 48 h

With sodium hydroxide; phosphorus pentachloride; potassium carbonate; triethylamine; trichlorophosphate; In ethanol; dichloromethane; acetone; 1: Methylation / 2: Chlorination / 3: Condensation / 4: Alkylation;
DOI:10.1021/jm990040h

Reference yield:

: 56875-60-6
7-Methoxy-2-naphthalenesulfonyl chloride

: 186551-71-3
7-methoxynaphthalene-2-sulfonic acid [1-(3-cyanobenzyl)-2-oxopyrrolidin-3-(S)-yl](N-tert-butyloxycarbonylpyrazol-3-ylmethyl)amide

Guidance literature:: Multi-step reaction with 2 steps

1: Et₃N / CH₂Cl₂ / 2 h

2: K₂CO₃ / acetone / 48 h

With potassium carbonate; triethylamine; In dichloromethane; acetone; 1: Condensation / 2: Alkylation;
DOI:10.1021/jm990040h