methyl 11-benzyl-1-morpholino-3-phenyl-11H-indolizino[8,7-b]indole-5-carboxylate

Base Information

• Chemical Name: methyl 11-benzyl-1-morpholino-3-phenyl-11H-indolizino[8,7-b]indole-5-carboxylate
• CAS No.: 1413922-12-9
• Molecular Formula: C₃₃H₂₉N₃O₃
• Molecular Weight: 515.612
• Mol file: 1413922-12-9.mol

Synonyms:methyl 11-benzyl-1-morpholino-3-phenyl-11H-indolizino[8,7-b]indole-5-carboxylate

Chemical Property of methyl 11-benzyl-1-morpholino-3-phenyl-11H-indolizino[8,7-b]indole-5-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 11-benzyl-1-morpholino-3-phenyl-11H-indolizino[8,7-b]indole-5-carboxylate

There total 1 articles about methyl 11-benzyl-1-morpholino-3-phenyl-11H-indolizino[8,7-b]indole-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

morpholine (110-91-8,99108-56-2) + methyl 9-benzyl-1-formyl-9H-β-carboline-3-carboxylate (1239512-29-8) + phenylacetylene (536-74-3) → methyl 11-benzyl-1-morpholino-3-phenyl-11H-indolizino[8,7-b]indole-5-carboxylate (1413922-12-9)

Guidance literature:

With copper(l) iodide; In toluene; at 85 ℃; for 8.16667h; Inert atmosphere;

DOI:10.1021/co300123y

Reference yield: 90.0%

methyl 11-benzyl-1-morpholino-3-phenyl-11H-indolizino[8,7-b]indole-5-carboxylate (1413922-12-9) → (E)-methyl 11-benzyl-11b-(3-(9-benzyl-3-(methoxycarbonyl)-9H-pyrido[3,4-b]indol-1-yl)-3-oxo-1-phenylprop-1-enyl)-1-oxo-3-phenyl-11,11b-dihydro-1H-indolizino[8,7-b]indole-5-carboxylate

Guidance literature:

With methanesulfonic acid; In dichloromethane; water; at 20 ℃; for 6h; Inert atmosphere;

DOI:10.1021/acs.orglett.6b02794

Reference yield:

methyl 11-benzyl-1-morpholino-3-phenyl-11H-indolizino[8,7-b]indole-5-carboxylate (1413922-12-9) → C58H42N4O4(18)O2

Guidance literature:

With methanesulfonic acid; ¹⁸O-labeled water; In dichloromethane; at 20 ℃; for 6h; Inert atmosphere;

DOI:10.1021/acs.orglett.6b02794

upstream raw materials:

morpholine

methyl 9-benzyl-1-formyl-9H-β-carboline-3-carboxylate

phenylacetylene