N'-[7-(acetylamino)-2-[[[(4-fluoro-3-methylphenyl)methyl]amino]carbonyl]-6,7,8,9-tetrahydro-3-hydroxy-4-oxo-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl]-N,N-dimethyl-ethanediamide

Base Information

Chemical Name:N'-[7-(acetylamino)-2-[[[(4-fluoro-3-methylphenyl)methyl]amino]carbonyl]-6,7,8,9-tetrahydro-3-hydroxy-4-oxo-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl]-N,N-dimethyl-ethanediamide
CAS No.:1380662-92-9
Molecular Formula:C₂₆H₃₁FN₆O₆
Molecular Weight:542.567
Hs Code.:

N'-[7-(acetylamino)-2-[[[(4-fluoro-3-methylphenyl)methyl]amino]carbonyl]-6,7,8,9-tetrahydro-3-hydroxy-4-oxo-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl]-N,N-dimethyl-ethanediamide

Synonyms:N'-[7-(acetylamino)-2-[[[(4-fluoro-3-methylphenyl)methyl]amino]carbonyl]-6,7,8,9-tetrahydro-3-hydroxy-4-oxo-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl]-N,N-dimethyl-ethanediamide

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Chemical Property of N'-[7-(acetylamino)-2-[[[(4-fluoro-3-methylphenyl)methyl]amino]carbonyl]-6,7,8,9-tetrahydro-3-hydroxy-4-oxo-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl]-N,N-dimethyl-ethanediamide

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Technology Process of N'-[7-(acetylamino)-2-[[[(4-fluoro-3-methylphenyl)methyl]amino]carbonyl]-6,7,8,9-tetrahydro-3-hydroxy-4-oxo-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl]-N,N-dimethyl-ethanediamide

There total 9 articles about N'-[7-(acetylamino)-2-[[[(4-fluoro-3-methylphenyl)methyl]amino]carbonyl]-6,7,8,9-tetrahydro-3-hydroxy-4-oxo-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl]-N,N-dimethyl-ethanediamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 6.0%

: 1380665-40-6
N-[7-(acetylamino)-2-[[[(4-fluoro-3-methylphenyl)methyl]amino]carbonyl]-6,7,8,9-tetrahydro-3-methoxy-4-oxo-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl]-N₁,N₁-dimethyl-ethanediamide

: 1380662-92-9
N'-[7-(acetylamino)-2-[[[(4-fluoro-3-methylphenyl)methyl]amino]carbonyl]-6,7,8,9-tetrahydro-3-hydroxy-4-oxo-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl]-N,N-dimethyl-ethanediamide

Guidance literature:: With lithium chloride; In N,N-dimethyl-formamide; at 120 ℃; for 1h;

Reference yield:

: 1380665-18-8
N-[7-[(acetyloxy)methyl]-2-[[[(4-fluoro-3-methylphenyl)methyl]amino]carbonyl]-6,7,8,9-tetrahydro-3-methoxy-4-oxo-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl]-carbamic acid phenylmethyl ester

: 1380662-92-9
N'-[7-(acetylamino)-2-[[[(4-fluoro-3-methylphenyl)methyl]amino]carbonyl]-6,7,8,9-tetrahydro-3-hydroxy-4-oxo-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl]-N,N-dimethyl-ethanediamide

Guidance literature:: Multi-step reaction with 10 steps

1: hydrogen / palladium 10% on activated carbon / methanol

2: 4-methyl-morpholine; HATU / 1 h

3: sodium carbonate / acetonitrile; water; methanol / 1 h

4: Dess-Martin periodane / dichloromethane

5: sodium chlorite; sodium dihydrogenphosphate / water; tert-butyl alcohol / 0.75 h

6: triethylamine; diphenyl phosphoryl azide / dichloromethane / 1 h / Inert atmosphere

7: dichloromethane / 1 h / Inert atmosphere; Reflux

8: hydrogenchloride / water; tetrahydrofuran

9: triethylamine / dichloromethane / 1 h

10: lithium chloride / N,N-dimethyl-formamide / 1 h / 120 °C

With 4-methyl-morpholine; hydrogenchloride; sodium chlorite; sodium dihydrogenphosphate; diphenyl phosphoryl azide; hydrogen; sodium carbonate; Dess-Martin periodane; triethylamine; HATU; lithium chloride; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol;

Reference yield:

: 1380665-27-9
C₂₆H₃₀FN₅O₇

: 1380662-92-9
N'-[7-(acetylamino)-2-[[[(4-fluoro-3-methylphenyl)methyl]amino]carbonyl]-6,7,8,9-tetrahydro-3-hydroxy-4-oxo-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl]-N,N-dimethyl-ethanediamide

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine; diphenyl phosphoryl azide / dichloromethane / 1 h / Inert atmosphere

2: dichloromethane / 1 h / Inert atmosphere; Reflux

3: hydrogenchloride / water; tetrahydrofuran

4: triethylamine / dichloromethane / 1 h

5: lithium chloride / N,N-dimethyl-formamide / 1 h / 120 °C

With hydrogenchloride; diphenyl phosphoryl azide; triethylamine; lithium chloride; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;