3-fluoro-4-((6-methoxy-7-(3-(piperdine-1-yl)propoxy)quinolin-4-yl)oxy)aniline

Base Information

Chemical Name:3-fluoro-4-((6-methoxy-7-(3-(piperdine-1-yl)propoxy)quinolin-4-yl)oxy)aniline
CAS No.:960299-69-8
Molecular Formula:C₂₄H₂₈FN₃O₃
Molecular Weight:425.503
Hs Code.:

Synonyms:3-fluoro-4-((6-methoxy-7-(3-(piperdine-1-yl)propoxy)quinolin-4-yl)oxy)aniline

Suppliers and Price of 3-fluoro-4-((6-methoxy-7-(3-(piperdine-1-yl)propoxy)quinolin-4-yl)oxy)aniline

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-fluoro-4-((6-methoxy-7-(3-(piperdine-1-yl)propoxy)quinolin-4-yl)oxy)aniline

Chemical Property:

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Technology Process of 3-fluoro-4-((6-methoxy-7-(3-(piperdine-1-yl)propoxy)quinolin-4-yl)oxy)aniline

There total 16 articles about 3-fluoro-4-((6-methoxy-7-(3-(piperdine-1-yl)propoxy)quinolin-4-yl)oxy)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1436418-00-6
4-(2-fluoro-4-nitrophenoxy)-6-methoxy-7-(3-(piperidin-1-yl)propoxy)quinoline

: 960299-69-8
3-fluoro-4-((6-methoxy-7-(3-(piperdine-1-yl)propoxy)quinolin-4-yl)oxy)aniline

Guidance literature:: With hydrogenchloride; iron; In ethanol; at 80 ℃; for 2h; Reflux;

Reference yield:

: 1160707-44-7
1-[4-(3-chloropropoxy)-5-methoxy-2-nitrophenyl]ethan-1-one

: 960299-69-8
3-fluoro-4-((6-methoxy-7-(3-(piperdine-1-yl)propoxy)quinolin-4-yl)oxy)aniline

Guidance literature:: Multi-step reaction with 6 steps

1: toluene / 10 h / 110 °C

2: acetic acid / 2 h / 60 - 80 °C

3: acetonitrile / 10 h / 85 °C

4: trichlorophosphate / acetonitrile / 6 h / 85 °C

5: chlorobenzene / 30 h / 140 °C

6: ammonium chloride; iron / ethanol; water / 5 h / Reflux

With iron; ammonium chloride; trichlorophosphate; In ethanol; water; acetic acid; chlorobenzene; toluene; acetonitrile;
DOI:10.1016/j.bmc.2013.04.013

Reference yield:

: 1394166-09-6,1428788-16-2
6-methyloxy-7-(4-(3-chloropropoxy))-4-4-hydroxyquinoline

: 960299-69-8
3-fluoro-4-((6-methoxy-7-(3-(piperdine-1-yl)propoxy)quinolin-4-yl)oxy)aniline

Guidance literature:: Multi-step reaction with 4 steps

1: acetonitrile / 10 h / 85 °C

2: trichlorophosphate / acetonitrile / 6 h / 85 °C

3: chlorobenzene / 30 h / 140 °C

4: ammonium chloride; iron / ethanol; water / 5 h / Reflux

With iron; ammonium chloride; trichlorophosphate; In ethanol; water; chlorobenzene; acetonitrile;
DOI:10.1016/j.bmc.2013.04.013