(3R)-3-<<(3'R)-3'-(benzyloxy)butanoyl>oxy>butanoic acid tert-butyl ester

Base Information

Chemical Name:(3R)-3-<<(3'R)-3'-(benzyloxy)butanoyl>oxy>butanoic acid tert-butyl ester
CAS No.:116761-27-4
Molecular Formula:C₁₉H₂₈O₅
Molecular Weight:336.428
Hs Code.:

Synonyms:(3R)-3-<<(3'R)-3'-(benzyloxy)butanoyl>oxy>butanoic acid tert-butyl ester

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Chemical Property of (3R)-3-<<(3'R)-3'-(benzyloxy)butanoyl>oxy>butanoic acid tert-butyl ester

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Technology Process of (3R)-3-<<(3'R)-3'-(benzyloxy)butanoyl>oxy>butanoic acid tert-butyl ester

There total 7 articles about (3R)-3-<<(3'R)-3'-(benzyloxy)butanoyl>oxy>butanoic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 110171-06-7
tert-butyl (R)-3-hydroxybutanoate

: 107265-56-5
(R)-3-(benzyloxy)butanoyl chloride

: 116761-27-4
(3R)-3-<<(3'R)-3'-(benzyloxy)butanoyl>oxy>butanoic acid tert-butyl ester

Guidance literature:: With pyridine; In dichloromethane; for 15h; Ambient temperature;
DOI:10.1002/hlca.19930760518

Reference yield:

: 116761-25-2
(R)-3-(benzyloxy)butanoic acid-(tert-butyl)ester

: 116761-27-4
(3R)-3-<<(3'R)-3'-(benzyloxy)butanoyl>oxy>butanoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 86 percent / hydrogen / Pd/C / ethanol / 20 °C

2: 48 percent / triethylamine / CHCl₃ / 20 °C / ice-water cooling

With hydrogen; triethylamine; palladium on activated charcoal; In ethanol; chloroform; 1: Hydrogenolysis / 2: Esterification;
DOI:10.1246/bcsj.71.1683

Reference yield:

: 81927-55-1
O-benzyl 2,2,2-trichloroacetimidate

: 116761-27-4
(3R)-3-<<(3'R)-3'-(benzyloxy)butanoyl>oxy>butanoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: CF₃SO₃H / CH₂Cl₂; hexane / 4 h / Ambient temperature

2: NaOH / methanol / Ambient temperature

3: SOCl₂ / CH₂Cl₂; dimethylformamide / Ambient temperature

4: pyridine / CH₂Cl₂ / -78 °C / to RT

With pyridine; sodium hydroxide; thionyl chloride; trifluorormethanesulfonic acid; In methanol; hexane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/(SICI)1522-2675(19981216)81:12<2430::AID-HLCA2430>3.0.CO;2-W