(R)-1-(3-CHLOROPHENYL)-1-HYDROXY-2-AMINOETHANE

Base Information

• Chemical Name: (R)-1-(3-CHLOROPHENYL)-1-HYDROXY-2-AMINOETHANE
• CAS No.: 121652-86-6
• Molecular Formula: C8H10ClNO
• Molecular Weight: 171.626
• Mol file: 121652-86-6.mol

Synonyms:Benzenemethanol,α-(aminomethyl)-3-chloro-,(R)-;(1R)-2-Amino-1-(3-chlorophenyl)ethanol;(R)-1-(3-Chlorophenyl)-1-hydroxy-2-aminoethanel;

Chemical Property of (R)-1-(3-CHLOROPHENYL)-1-HYDROXY-2-AMINOETHANE

Chemical Property:

• Boiling Point: 319.8 °C at 760 mmHg
• PKA: 11.77±0.35(Predicted)
• Flash Point: 147.2 °C
• PSA: 46.25000
• Density: 1.26 g/cm³
• LogP: 2.03240

Purity/Quality:

97% ^*data from raw suppliers

(R)-2-Amino-1-(3-chlorophenyl)ethanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-1-(3-CHLOROPHENYL)-1-HYDROXY-2-AMINOETHANE

There total 6 articles about (R)-1-(3-CHLOROPHENYL)-1-HYDROXY-2-AMINOETHANE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

(R)-meta-chlorostyrene oxide (20697-04-5,53631-04-2,115648-90-3,62600-71-9) → (R)-2-(3-Chlorophenyl)-2-hydroxyethylamine (121652-86-6)

Guidance literature:

With sodium hexamethyldisilazane; In tetrahydrofuran; at 0 - 20 ℃;

Reference yield: 93.7%

(R)-3-chloromandelamide (859931-64-9) → (R)-2-(3-Chlorophenyl)-2-hydroxyethylamine (121652-86-6)

Guidance literature:

sodium tetrahydroborate; sulfuric acid; In 1,2-dimethoxyethane; at 70 ℃; for 3h; Heating / reflux;

Reference yield:

(R)-2-(2-(3-chlorophenyl)-2-hydroxyethyl)isoindoline-1,3-dione → (R)-2-(3-Chlorophenyl)-2-hydroxyethylamine (121652-86-6)

Guidance literature:

With sodium hydroxide; hydrazine hydrate; In ethanol; water;

upstream raw materials:

(2R)-2-(3-chlorophenyl)-2-trimethylsilyloxyacetonitrile

m-Chlorobenzaldehyde

(R)-3-chloromandelamide

(R)-meta-chlorostyrene oxide

Downstream raw materials:

3-chloroalpha-(((2-(3,4-dimethoxyphenyl)-1-methylethyl)amino)methyl)-benzenemethanol

5-{2-[2-(3-Chloro-phenyl)-2(R)-hydroxy-ethylamino]-propyl}-1-phenylacetyl-1,3-dihydro-indole-2,2-dicarboxylic acid dimethyl ester