(-)-1-chloro-4-(1R,2R)-(2-(trifluoromethyl)cyclopropyl)benzene

Base Information

• Chemical Name: (-)-1-chloro-4-(1R,2R)-(2-(trifluoromethyl)cyclopropyl)benzene
• CAS No.: 1276183-95-9
• Molecular Formula: C₁₀H₈ClF₃
• Molecular Weight: 220.622
• Mol file: 1276183-95-9.mol

Synonyms:(-)-1-chloro-4-(1R,2R)-(2-(trifluoromethyl)cyclopropyl)benzene

Chemical Property of (-)-1-chloro-4-(1R,2R)-(2-(trifluoromethyl)cyclopropyl)benzene

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of (-)-1-chloro-4-(1R,2R)-(2-(trifluoromethyl)cyclopropyl)benzene

There total 2 articles about (-)-1-chloro-4-(1R,2R)-(2-(trifluoromethyl)cyclopropyl)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

4-vinylbenzyl chloride (1073-67-2,24991-47-7) + 2,2,2-trifluorodiazoethane (371-67-5) → (-)-1-chloro-4-(1R,2R)-(2-(trifluoromethyl)cyclopropyl)benzene (1276183-95-9)

Guidance literature:

With Ru-pheox; In dichloromethane; at 20 ℃; stereoselective reaction;

DOI:10.1039/c8cc02286k

Reference yield:

4-vinylbenzyl chloride (1073-67-2,24991-47-7) + 2,2,2-trifluroethylamine hydrochloride (373-88-6) → (+)-1-chloro-4-(1S,2S)-(2-(trifluoromethyl)cyclopropyl)benzene + (-)-1-chloro-4-(1R,2R)-(2-(trifluoromethyl)cyclopropyl)benzene (1276183-95-9)

Guidance literature:

With triphenyl-arsane; sulfuric acid; C₂₈H₃₆CoN₂O₄; sodium acetate; sodium chloride; sodium nitrite; In water; at -15 ℃; for 14h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;

DOI:10.1002/anie.201004269

Reference yield: 81.0%

(-)-1-chloro-4-(1R,2R)-(2-(trifluoromethyl)cyclopropyl)benzene (1276183-95-9) + thiophenol (108-98-5) → 4-(4-chlorophenyl)-1,1-difluoro-4-(phenylsulfanyl)but-1-ene

Guidance literature:

thiophenol; With sodium hydride; In dichloromethane; at 20 ℃;

(-)-1-chloro-4-(1R,2R)-(2-(trifluoromethyl)cyclopropyl)benzene; With dimethylaluminum chloride; In dichloromethane; at -20 - 40 ℃; for 2h;

DOI:10.1021/acs.orglett.0c00385

upstream raw materials:

4-vinylbenzyl chloride

2,2,2-trifluroethylamine hydrochloride

2,2,2-trifluorodiazoethane