3-(4-chlorophenyl)-4-(2-(3,5-bis(trifluoromethyl)phenyl)hydrazono)-5-trifluoromethyl-4H-pyrazole

Base Information

Chemical Name:3-(4-chlorophenyl)-4-(2-(3,5-bis(trifluoromethyl)phenyl)hydrazono)-5-trifluoromethyl-4H-pyrazole
CAS No.:1312886-46-6
Molecular Formula:C₁₈H₈ClF₉N₄
Molecular Weight:486.727
Hs Code.:

Synonyms:3-(4-chlorophenyl)-4-(2-(3,5-bis(trifluoromethyl)phenyl)hydrazono)-5-trifluoromethyl-4H-pyrazole

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Chemical Property of 3-(4-chlorophenyl)-4-(2-(3,5-bis(trifluoromethyl)phenyl)hydrazono)-5-trifluoromethyl-4H-pyrazole

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Technology Process of 3-(4-chlorophenyl)-4-(2-(3,5-bis(trifluoromethyl)phenyl)hydrazono)-5-trifluoromethyl-4H-pyrazole

There total 3 articles about 3-(4-chlorophenyl)-4-(2-(3,5-bis(trifluoromethyl)phenyl)hydrazono)-5-trifluoromethyl-4H-pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1312886-40-0
1-(4-chlorophenyl)-2-(2-(3,5-bis(trifluoromethyl)phenyl)hydrazono)-4,4,4-trifluorobutane-1,3-dione

: 1312886-46-6
3-(4-chlorophenyl)-4-(2-(3,5-bis(trifluoromethyl)phenyl)hydrazono)-5-trifluoromethyl-4H-pyrazole

Guidance literature:: With hydrazine hydrate; In ethanol; for 4h; Reflux;
DOI:10.1016/j.bmc.2011.04.027

Reference yield:

: 18931-60-7
1-(4-chlorophenyl)-4,4,4-trifluorobutane-1,3-dione

: 1312886-46-6
3-(4-chlorophenyl)-4-(2-(3,5-bis(trifluoromethyl)phenyl)hydrazono)-5-trifluoromethyl-4H-pyrazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride; sodium nitrite / water / 2.67 h / 20 °C / Cooling with ice

1.2: 0.75 h / Cooling with ice

2.1: hydrazine hydrate / ethanol / 4 h / Reflux

With hydrogenchloride; hydrazine hydrate; sodium nitrite; In ethanol; water;
DOI:10.1016/j.bmc.2011.04.027

Reference yield:

: 99-91-2
para-chloroacetophenone

: 1312886-46-6
3-(4-chlorophenyl)-4-(2-(3,5-bis(trifluoromethyl)phenyl)hydrazono)-5-trifluoromethyl-4H-pyrazole

Guidance literature:: Multi-step reaction with 3 steps

2.1: hydrogenchloride; sodium nitrite / water / 2.67 h / 20 °C / Cooling with ice

2.2: 0.75 h / Cooling with ice

3.1: hydrazine hydrate / ethanol / 4 h / Reflux

With hydrogenchloride; hydrazine hydrate; sodium nitrite; In ethanol; water; 1.1: Claisen-Schmidt condensation;
DOI:10.1016/j.bmc.2011.04.027