2,2,2-trichloroethyl difluoro(4-iodophenyl)methanesulfonate

Base Information

• Chemical Name: 2,2,2-trichloroethyl difluoro(4-iodophenyl)methanesulfonate
• CAS No.: 345915-68-6
• Molecular Formula: C₉H₆Cl₃F₂IO₃S
• Molecular Weight: 465.471
• Mol file: 345915-68-6.mol

Synonyms:2,2,2-trichloroethyl difluoro(4-iodophenyl)methanesulfonate

Chemical Property of 2,2,2-trichloroethyl difluoro(4-iodophenyl)methanesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,2,2-trichloroethyl difluoro(4-iodophenyl)methanesulfonate

There total 1 articles about 2,2,2-trichloroethyl difluoro(4-iodophenyl)methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

2,2,2-trichloroethyl (4-iodo-phenyl)methanesulfonate (345915-66-4) → difluoro-(4-iodo-phenyl)methanesulfonic acid 2,2-dichlorovinyl ester + 2,2,2-trichloroethyl difluoro(4-iodophenyl)methanesulfonate (345915-68-6)

Guidance literature:

With sodium hexamethyldisilazane; N-fluorobis(benzenesulfon)imide; In tetrahydrofuran; at -78 - 20 ℃;

DOI:10.1021/ol0158664

Reference yield: 44.0%

2,2,2-trichloroethyl difluoro(4-iodophenyl)methanesulfonate (345915-68-6) + C19H18INO4Zn → methyl 3-(4-{difluoro[(2,2,2-trichloroethoxy)sulfonyl]methyl}phenyl)-2-{[(9H-9-fluorenylmethoxy)carbonyl]amino}propanoate

Guidance literature:

2,2,2-trichloroethyl difluoro(4-iodophenyl)methanesulfonate; With diisobutylaluminium hydride; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; hexane; N,N-dimethyl acetamide; at 20 ℃;

C₁₉H₁₈INO₄Zn; In tetrahydrofuran; hexane; N,N-dimethyl acetamide; at 65 - 70 ℃; for 6h; Further stages.;

DOI:10.1021/ol0158664

Reference yield:

2,2,2-trichloroethyl difluoro(4-iodophenyl)methanesulfonate (345915-68-6) → 3-(4-{difluoro[(2,2,2-trichloroethoxy)sulfonyl]methyl}phenyl)-2-{[(9H-9-fluorenylmethoxy)carbonyl]amino}propanoic acid

Guidance literature:

Multi-step reaction with 2 steps

1.1: diisobutylaluminum hydride / PdCl₂(PPh₃)2 / tetrahydrofuran; N,N-dimethyl-acetamide; hexane / 20 °C

1.2: 44 percent / tetrahydrofuran; N,N-dimethyl-acetamide; hexane / 6 h / 65 - 70 °C

2.1: 89 percent / LiOH / tetrahydrofuran; H₂O / 0 °C

With lithium hydroxide; diisobutylaluminium hydride; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; hexane; N,N-dimethyl acetamide; water;

DOI:10.1021/ol0158664

upstream raw materials:

2,2,2-trichloroethyl (4-iodo-phenyl)methanesulfonate