tert-butyl 2-(5-chloro-1H-indol-3-yl)-1-(4-phenyl-1H-imidazol-2-yl)ethylcarbamate

Base Information

Chemical Name:tert-butyl 2-(5-chloro-1H-indol-3-yl)-1-(4-phenyl-1H-imidazol-2-yl)ethylcarbamate
CAS No.:361576-60-5
Molecular Formula:C₂₄H₂₅ClN₄O₂
Molecular Weight:436.941
Hs Code.:

Synonyms:tert-butyl 2-(5-chloro-1H-indol-3-yl)-1-(4-phenyl-1H-imidazol-2-yl)ethylcarbamate

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Chemical Property of tert-butyl 2-(5-chloro-1H-indol-3-yl)-1-(4-phenyl-1H-imidazol-2-yl)ethylcarbamate

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Technology Process of tert-butyl 2-(5-chloro-1H-indol-3-yl)-1-(4-phenyl-1H-imidazol-2-yl)ethylcarbamate

There total 4 articles about tert-butyl 2-(5-chloro-1H-indol-3-yl)-1-(4-phenyl-1H-imidazol-2-yl)ethylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-tert-butoxycarbonylamino-3-(5-chloro-1H-indol-3-yl)-propionic acid 2-oxo-2-phenyl-ethyl ester

: 361576-60-5
tert-butyl 2-(5-chloro-1H-indol-3-yl)-1-(4-phenyl-1H-imidazol-2-yl)ethylcarbamate

Guidance literature:: With ammonium acetate; In xylene; for 0.75h; Heating;
DOI:10.1021/jm0108449

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 361576-60-5
tert-butyl 2-(5-chloro-1H-indol-3-yl)-1-(4-phenyl-1H-imidazol-2-yl)ethylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 84 percent / dioxane / 2 h / Heating

2.1: Cs₂CO₃ / ethanol / 0.5 h / 20 °C

2.2: dimethylformamide / 1 h / 20 °C

3.1: NH₄OAc / xylene / 0.75 h / Heating

With ammonium acetate; caesium carbonate; In 1,4-dioxane; ethanol; xylene;
DOI:10.1021/jm0108449

Reference yield:

: 154-07-4
2-amino-3-(5-chloro-1H-indol-3-yl)propanoic acid

: 361576-60-5
tert-butyl 2-(5-chloro-1H-indol-3-yl)-1-(4-phenyl-1H-imidazol-2-yl)ethylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 84 percent / dioxane / 2 h / Heating

2.1: Cs₂CO₃ / ethanol / 0.5 h / 20 °C

2.2: dimethylformamide / 1 h / 20 °C

3.1: NH₄OAc / xylene / 0.75 h / Heating

With ammonium acetate; caesium carbonate; In 1,4-dioxane; ethanol; xylene;
DOI:10.1021/jm0108449