5-[1-(2,4-dichlorobenzyl)-5-fluoro-3-methyl-1H-indol-7-yl]-isoxazol-3-ylamine

Base Information

Chemical Name:5-[1-(2,4-dichlorobenzyl)-5-fluoro-3-methyl-1H-indol-7-yl]-isoxazol-3-ylamine
CAS No.:885226-16-4
Molecular Formula:C₁₉H₁₄Cl₂FN₃O
Molecular Weight:390.244
Hs Code.:

Synonyms:5-[1-(2,4-dichlorobenzyl)-5-fluoro-3-methyl-1H-indol-7-yl]-isoxazol-3-ylamine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-[1-(2,4-dichlorobenzyl)-5-fluoro-3-methyl-1H-indol-7-yl]-isoxazol-3-ylamine

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Technology Process of 5-[1-(2,4-dichlorobenzyl)-5-fluoro-3-methyl-1H-indol-7-yl]-isoxazol-3-ylamine

There total 3 articles about 5-[1-(2,4-dichlorobenzyl)-5-fluoro-3-methyl-1H-indol-7-yl]-isoxazol-3-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: C₁₉H₁₆Cl₂FN₃O₂

: 885226-16-4
5-[1-(2,4-dichlorobenzyl)-5-fluoro-3-methyl-1H-indol-7-yl]-isoxazol-3-ylamine

Guidance literature:: With hydrogenchloride; In water; at 90 ℃; for 2h;
DOI:10.1016/j.tetlet.2009.11.073

Reference yield: 43.0%

: 885225-95-6
3-[1-(2,4-dichloro-benzyl)-5-fluoro-3-methyl-1H-indol-7-yl]-3-oxo-propionitrile

: 885226-16-4
5-[1-(2,4-dichlorobenzyl)-5-fluoro-3-methyl-1H-indol-7-yl]-isoxazol-3-ylamine

Guidance literature:: 3-[1-(2,4-dichloro-benzyl)-5-fluoro-3-methyl-1H-indol-7-yl]-3-oxo-propionitrile; With hydroxyammonium sulfate; sodium hydroxide; In ethanol; water; for 20h; Reflux;

With hydrogenchloride; In ethanol; water; for 2h; regioselective reaction; Reflux;
DOI:10.1016/j.tetlet.2009.11.073

Reference yield: 39.0%

: 885225-95-6
3-[1-(2,4-dichloro-benzyl)-5-fluoro-3-methyl-1H-indol-7-yl]-3-oxo-propionitrile

: 885226-16-4
5-[1-(2,4-dichlorobenzyl)-5-fluoro-3-methyl-1H-indol-7-yl]-isoxazol-3-ylamine

: 1208065-25-1
C₁₉H₁₄Cl₂FN₃O

: C₁₉H₁₆Cl₂FN₃O₂

Guidance literature:: With hydroxylamine hydrochloride; sodium hydroxide; In ethanol; water; at 80 ℃; for 10h;
DOI:10.1016/j.tetlet.2009.11.073