3-(3-fluoro-4-((pyrrolidin-1-yl)methyl)phenyl)-N-isobutylcyclobut-2-enecarboxamide trifluoroacetate

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Chemical Name:3-(3-fluoro-4-((pyrrolidin-1-yl)methyl)phenyl)-N-isobutylcyclobut-2-enecarboxamide trifluoroacetate
CAS No.:935841-12-6
Molecular Formula:C₂HF₃O₂*C₂₀H₂₇FN₂O
Molecular Weight:444.47
Hs Code.:

Synonyms:3-(3-fluoro-4-((pyrrolidin-1-yl)methyl)phenyl)-N-isobutylcyclobut-2-enecarboxamide trifluoroacetate

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Chemical Property of 3-(3-fluoro-4-((pyrrolidin-1-yl)methyl)phenyl)-N-isobutylcyclobut-2-enecarboxamide trifluoroacetate

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Technology Process of 3-(3-fluoro-4-((pyrrolidin-1-yl)methyl)phenyl)-N-isobutylcyclobut-2-enecarboxamide trifluoroacetate

There total 1 articles about 3-(3-fluoro-4-((pyrrolidin-1-yl)methyl)phenyl)-N-isobutylcyclobut-2-enecarboxamide trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 935840-60-1
3-(3-fluoro-4-pyrrolidin-1-ylmethyl-phenyl)-3-hydroxy-cyclobutanecarboxylic acid isobutyl-amide

: 76-05-1
trifluoroacetic acid

: 935841-12-6
3-(3-fluoro-4-((pyrrolidin-1-yl)methyl)phenyl)-N-isobutylcyclobut-2-enecarboxamide trifluoroacetate

Guidance literature:: In 1,2-dichloro-ethane; at 75 ℃; for 18 - 21h; Product distribution / selectivity; Heating / reflux;

Reference yield: 54.0%

: 935841-12-6
3-(3-fluoro-4-((pyrrolidin-1-yl)methyl)phenyl)-N-isobutylcyclobut-2-enecarboxamide trifluoroacetate

: 3-(3-fluoro-4-pyrrolidin-1-ylmethyl-phenyl)-cyclobutanecarboxylic acid isobutyl-amide

Guidance literature:: 3-(3-fluoro-4-((pyrrolidin-1-yl)methyl)phenyl)-N-isobutylcyclobut-2-enecarboxamide trifluoroacetate; With hydrogen; palladium 10% on activated carbon; In ethanol; at 20 ℃; for 2h; under 2327.23 Torr;

With potassium carbonate; In water; ethyl acetate; Product distribution / selectivity;