2-(1,1-difluoroethyl)-5-methyl-N-[4-(pentafluoro-λ⁶-sulfanyl)phenyl]-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine

Base Information

• Chemical Name: 2-(1,1-difluoroethyl)-5-methyl-N-[4-(pentafluoro-λ⁶-sulfanyl)phenyl]-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
• CAS No.: 1282041-94-4
• Molecular Formula: C₁₄H₁₂F₇N₅S
• Molecular Weight: 415.338

Synonyms:2-(1,1-difluoroethyl)-5-methyl-N-[4-(pentafluoro-λ⁶-sulfanyl)phenyl]-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine

Chemical Property of 2-(1,1-difluoroethyl)-5-methyl-N-[4-(pentafluoro-λ⁶-sulfanyl)phenyl]-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

DSM265 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: DSM265, inhibits the growth of P. falciparum 3D7 parasites with an EC50 of 4.3 nM. It is also a PfDHODH inhibitor with an IC50 of 8.9 nM.

Technology Process of 2-(1,1-difluoroethyl)-5-methyl-N-[4-(pentafluoro-λ⁶-sulfanyl)phenyl]-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine

There total 3 articles about 2-(1,1-difluoroethyl)-5-methyl-N-[4-(pentafluoro-λ⁶-sulfanyl)phenyl]-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

7-chloro-2-(1,1-difluoroethyl)-5-methyl[1,2,4]triazolo[1,5-a] pyrimidine (1281860-67-0) + 4-(pentafluorosulfanyl)aniline (2993-24-0) → 2-(1,1-difluoroethyl)-5-methyl-N-[4-(pentafluoro-λ6-sulfanyl)phenyl]-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine (1282041-94-4)

Guidance literature:

In ethanol; Reflux;

DOI:10.1021/jm200592f

Reference yield:

2-(1,1-difluoroethyl)-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-ol (1281860-66-9) → 2-(1,1-difluoroethyl)-5-methyl-N-[4-(pentafluoro-λ6-sulfanyl)phenyl]-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine (1282041-94-4)

Guidance literature:

Multi-step reaction with 2 steps

1: trichlorophosphate / 2 h / Reflux

2: ethanol / 1 h / 50 °C

With trichlorophosphate; In ethanol;

Reference yield:

2,3-Diamino-6-methyl-4(3H)-pyrimidinone (35523-64-9) → 2-(1,1-difluoroethyl)-5-methyl-N-[4-(pentafluoro-λ6-sulfanyl)phenyl]-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine (1282041-94-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium ethanolate / 0.5 h / 80 °C

1.2: 2 h / 20 - 80 °C

1.3: pH 4

2.1: trichlorophosphate / 2 h / Reflux

3.1: ethanol / 1 h / 50 °C

With sodium ethanolate; trichlorophosphate; In ethanol;

upstream raw materials:

7-chloro-2-(1,1-difluoroethyl)-5-methyl[1,2,4]triazolo[1,5-a] pyrimidine

4-(pentafluorosulfanyl)aniline

2-(1,1-difluoroethyl)-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-ol

2,3-Diamino-6-methyl-4(3H)-pyrimidinone

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