acetic acid 4-{2-[2-(1H-indol-3-yl)-ethylcarbamoyl]-vinyl}-2-methoxy-phenyl ester

Base Information

• Chemical Name: acetic acid 4-{2-[2-(1H-indol-3-yl)-ethylcarbamoyl]-vinyl}-2-methoxy-phenyl ester
• CAS No.: 1027893-20-4
• Molecular Formula: C₂₂H₂₂N₂O₄
• Molecular Weight: 378.428

Synonyms:acetic acid 4-{2-[2-(1H-indol-3-yl)-ethylcarbamoyl]-vinyl}-2-methoxy-phenyl ester

Chemical Property of acetic acid 4-{2-[2-(1H-indol-3-yl)-ethylcarbamoyl]-vinyl}-2-methoxy-phenyl ester

Chemical Property:

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Technology Process of acetic acid 4-{2-[2-(1H-indol-3-yl)-ethylcarbamoyl]-vinyl}-2-methoxy-phenyl ester

There total 2 articles about acetic acid 4-{2-[2-(1H-indol-3-yl)-ethylcarbamoyl]-vinyl}-2-methoxy-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

tryptamine (61-54-1) + (E)-3-(4-acetoxy-3-methoxyphenyl)acrylic acid (2596-47-6,147677-05-2,34749-55-8) → acetic acid 4-{2-[2-(1H-indol-3-yl)-ethylcarbamoyl]-vinyl}-2-methoxy-phenyl ester (1027893-20-4)

Guidance literature:

(E)-3-(4-acetoxy-3-methoxyphenyl)acrylic acid; With pyridine; N,N-dimethylchloromethyleneiminium chloride; In tetrahydrofuran; at -30 ℃; for 1h;

tryptamine; With n-butyllithium; In tetrahydrofuran; at -30 - 20 ℃; for 2.16667h;

DOI:10.1021/jm050454c

Reference yield:

tryptamine (61-54-1) + 4-acetoxy-3-methoxycinnamoyl chloride (50906-12-2) → acetic acid 4-{2-[2-(1H-indol-3-yl)-ethylcarbamoyl]-vinyl}-2-methoxy-phenyl ester (1027893-20-4)

Guidance literature:

With pyridine; In toluene; at 20 ℃;

DOI:10.1016/j.lfs.2007.11.016

Reference yield: 100.0%

acetic acid 4-{2-[2-(1H-indol-3-yl)-ethylcarbamoyl]-vinyl}-2-methoxy-phenyl ester (1027893-20-4) → (E)-N-(2-(1H-indol-3-yl)ethyl)-3-(4-hydroxy-3-methoxyphenyl)acrylamide (96014-22-1)

Guidance literature:

With potassium carbonate; In methanol; for 20h;

DOI:10.1021/jm050454c

upstream raw materials:

tryptamine

(E)-3-(4-acetoxy-3-methoxyphenyl)acrylic acid

4-acetoxy-3-methoxycinnamoyl chloride

Downstream raw materials:

(E)-N-(2-(1H-indol-3-yl)ethyl)-3-(4-hydroxy-3-methoxyphenyl)acrylamide

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