2-[(2S)-2-{[bis(2-methylphenyl)phosphanyl]methyl}pyrrolidin-1-yl]-1,3-benzothiazole

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Chemical Name:2-[(2S)-2-{[bis(2-methylphenyl)phosphanyl]methyl}pyrrolidin-1-yl]-1,3-benzothiazole
CAS No.:1416046-11-1
Molecular Formula:C₂₆H₂₇N₂PS
Molecular Weight:430.554
Hs Code.:

Synonyms:2-[(2S)-2-{[bis(2-methylphenyl)phosphanyl]methyl}pyrrolidin-1-yl]-1,3-benzothiazole

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Chemical Property of 2-[(2S)-2-{[bis(2-methylphenyl)phosphanyl]methyl}pyrrolidin-1-yl]-1,3-benzothiazole

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Technology Process of 2-[(2S)-2-{[bis(2-methylphenyl)phosphanyl]methyl}pyrrolidin-1-yl]-1,3-benzothiazole

There total 5 articles about 2-[(2S)-2-{[bis(2-methylphenyl)phosphanyl]methyl}pyrrolidin-1-yl]-1,3-benzothiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 1416046-09-7
2-[(2S)-2-(bromomethyl)pyrrolidin-1-yl]-1,3-benzothiazole

: 29949-64-2
di(o-tolyl)phosphine

: 1416046-11-1
2-[(2S)-2-{[bis(2-methylphenyl)phosphanyl]methyl}pyrrolidin-1-yl]-1,3-benzothiazole

Guidance literature:: di(o-tolyl)phosphine; With n-butyllithium; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 2.33h;

2-[(2S)-2-(bromomethyl)pyrrolidin-1-yl]-1,3-benzothiazole; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 19h;
DOI:10.1002/hlca.201200437

Reference yield:

: 615-20-3
2-chlorobenzo[d][1,3]thiazole

: 1416046-11-1
2-[(2S)-2-{[bis(2-methylphenyl)phosphanyl]methyl}pyrrolidin-1-yl]-1,3-benzothiazole

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium / hexane; tetrahydrofuran / 1.5 h / -78 - 20 °C

1.2: 14 h / -78 - 20 °C / Inert atmosphere

2.1: tetra-n-butylammoniumfluoride trihydrate / tetrahydrofuran / 3 h / 0 - 20 °C

3.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 17 h / 0 - 20 °C

4.1: n-butyllithium / hexane; tetrahydrofuran / 2.33 h / -78 - 20 °C

4.2: 19 h / -78 - 20 °C

With n-butyllithium; carbon tetrabromide; tetra-n-butylammoniumfluoride trihydrate; triphenylphosphine; In tetrahydrofuran; hexane; dichloromethane; 3.1: |Appel Halogenation;
DOI:10.1002/hlca.201200437

Reference yield:

: 134756-75-5
(2S)-2-({[(tert-butyl)(dimethyl)silyl]oxy}methyl)pyrrolidine

: 1416046-11-1
2-[(2S)-2-{[bis(2-methylphenyl)phosphanyl]methyl}pyrrolidin-1-yl]-1,3-benzothiazole

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium / hexane; tetrahydrofuran / 1.5 h / -78 - 20 °C

1.2: 14 h / -78 - 20 °C / Inert atmosphere

2.1: tetra-n-butylammoniumfluoride trihydrate / tetrahydrofuran / 3 h / 0 - 20 °C

3.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 17 h / 0 - 20 °C

4.1: n-butyllithium / hexane; tetrahydrofuran / 2.33 h / -78 - 20 °C

4.2: 19 h / -78 - 20 °C

With n-butyllithium; carbon tetrabromide; tetra-n-butylammoniumfluoride trihydrate; triphenylphosphine; In tetrahydrofuran; hexane; dichloromethane; 3.1: |Appel Halogenation;
DOI:10.1002/hlca.201200437