(1R,4R,5S)-3-Benzenesulfonyl-5-(tert-butyl-dimethyl-silanyloxy)-2,4-dimethyl-cycloheptanol

Base Information

Chemical Name:(1R,4R,5S)-3-Benzenesulfonyl-5-(tert-butyl-dimethyl-silanyloxy)-2,4-dimethyl-cycloheptanol
CAS No.:474023-15-9
Molecular Formula:C₂₁H₃₆O₄SSi
Molecular Weight:412.666
Hs Code.:

Synonyms:(1R,4R,5S)-3-Benzenesulfonyl-5-(tert-butyl-dimethyl-silanyloxy)-2,4-dimethyl-cycloheptanol

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Chemical Property of (1R,4R,5S)-3-Benzenesulfonyl-5-(tert-butyl-dimethyl-silanyloxy)-2,4-dimethyl-cycloheptanol

Chemical Property:

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Technology Process of (1R,4R,5S)-3-Benzenesulfonyl-5-(tert-butyl-dimethyl-silanyloxy)-2,4-dimethyl-cycloheptanol

There total 4 articles about (1R,4R,5S)-3-Benzenesulfonyl-5-(tert-butyl-dimethyl-silanyloxy)-2,4-dimethyl-cycloheptanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 474023-09-1
(3-benzenesulfonyl-cyclohepta-2,4-dienyloxy)-tert-butyl-dimethyl-silane

: 474023-15-9
(1R,4R,5S)-3-Benzenesulfonyl-5-(tert-butyl-dimethyl-silanyloxy)-2,4-dimethyl-cycloheptanol

Guidance literature:: Multi-step reaction with 4 steps

1: tetrahydrofuran; diethyl ether / 0.33 h / -78 °C

2: 92 percent / m-CPBA / CH₂Cl₂ / 18 h / 20 °C

3: 97 percent / DBU / tetrahydrofuran / 5 h / Heating

4: tetrahydrofuran; diethyl ether / -78 - -10 °C

With 1,8-diazabicyclo[5.4.0]undec-7-ene; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1021/ja026760m

Reference yield:

: (3-benzenesulfonyl-2-methyl-cyclohept-4-enyloxy)-tert-butyl-dimethyl-silane

: 474023-15-9
(1R,4R,5S)-3-Benzenesulfonyl-5-(tert-butyl-dimethyl-silanyloxy)-2,4-dimethyl-cycloheptanol

Guidance literature:: Multi-step reaction with 3 steps

1: 92 percent / m-CPBA / CH₂Cl₂ / 18 h / 20 °C

2: 97 percent / DBU / tetrahydrofuran / 5 h / Heating

3: tetrahydrofuran; diethyl ether / -78 - -10 °C

With 1,8-diazabicyclo[5.4.0]undec-7-ene; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1021/ja026760m

Reference yield:

: 474023-11-5
(1R,2R,3R,4S,7R)-(2-benzenesulfonyl-3-methyl-8-oxabicyclo[5.1.0]oct-4-yloxy)-tert-butyldimethylsilane

: 474023-15-9
(1R,4R,5S)-3-Benzenesulfonyl-5-(tert-butyl-dimethyl-silanyloxy)-2,4-dimethyl-cycloheptanol

Guidance literature:: Multi-step reaction with 2 steps

1: 97 percent / DBU / tetrahydrofuran / 5 h / Heating

2: tetrahydrofuran; diethyl ether / -78 - -10 °C

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; diethyl ether;
DOI:10.1021/ja026760m