2-(4-difluoromethoxy-phenyl)-3-(4-methanesulfonyl-phenyl)-pyrazolo[1,5-b]pyridazine

Base Information

Chemical Name:2-(4-difluoromethoxy-phenyl)-3-(4-methanesulfonyl-phenyl)-pyrazolo[1,5-b]pyridazine
CAS No.:221148-48-7
Molecular Formula:C₂₀H₁₅F₂N₃O₃S
Molecular Weight:415.42
Hs Code.:

Synonyms:2-(4-difluoromethoxy-phenyl)-3-(4-methanesulfonyl-phenyl)-pyrazolo[1,5-b]pyridazine

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Chemical Property of 2-(4-difluoromethoxy-phenyl)-3-(4-methanesulfonyl-phenyl)-pyrazolo[1,5-b]pyridazine

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Technology Process of 2-(4-difluoromethoxy-phenyl)-3-(4-methanesulfonyl-phenyl)-pyrazolo[1,5-b]pyridazine

There total 5 articles about 2-(4-difluoromethoxy-phenyl)-3-(4-methanesulfonyl-phenyl)-pyrazolo[1,5-b]pyridazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

: 221148-25-0
4-[3-(4-methanesulfonyl-phenyl)-pyrazolo[1,5-bl]pyridazin-2-yl]-phenol

: 1511-62-2
bromodifluoromethane

: 221148-48-7
2-(4-difluoromethoxy-phenyl)-3-(4-methanesulfonyl-phenyl)-pyrazolo[1,5-b]pyridazine

Guidance literature:: In N-methyl-acetamide; ethyl acetate;

Reference yield:

: 3-bromo-2-(4-methoxy-phenyl)-pyrazolo[1,5-b]pyridazine

: 221148-48-7
2-(4-difluoromethoxy-phenyl)-3-(4-methanesulfonyl-phenyl)-pyrazolo[1,5-b]pyridazine

Guidance literature:: Multi-step reaction with 3 steps

1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 18 h / Heating / reflux

2: boron tribromide / dichloromethane / -70 - 0 °C

3: sodium hydride / N,N-dimethyl-formamide / 0.33 h

With boron tribromide; sodium hydride; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 781674-50-8
2-(4-methoxy-phenyl)-pyrazolo[1,5-b]pyridazine-3-carboxylic acid methyl ester

: 221148-48-7
2-(4-difluoromethoxy-phenyl)-3-(4-methanesulfonyl-phenyl)-pyrazolo[1,5-b]pyridazine

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydroxide; water / ethanol / 2 h / Heating / reflux

2: N-Bromosuccinimide; sodium carbonate / N,N-dimethyl-formamide / 1 h

3: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 18 h / Heating / reflux

4: boron tribromide / dichloromethane / -70 - 0 °C

5: sodium hydride / N,N-dimethyl-formamide / 0.33 h

With sodium hydroxide; N-Bromosuccinimide; water; boron tribromide; sodium hydride; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; ethanol; dichloromethane; water; N,N-dimethyl-formamide;