4-Amino-6-(((1S)-1-(5-((4-methyl-1-piperazinyl)carbonyl)-3-phenyl-imidazo[1,2-a]pyridin-2-yl)ethyl)amino)-5-pyrimidinecarbonitrile

Base Information

Chemical Name:4-Amino-6-(((1S)-1-(5-((4-methyl-1-piperazinyl)carbonyl)-3-phenyl-imidazo[1,2-a]pyridin-2-yl)ethyl)amino)-5-pyrimidinecarbonitrile
CAS No.:1338485-05-4
Molecular Formula:C₂₆H₂₇N₉O
Molecular Weight:481.56
Hs Code.:

Synonyms:4-Amino-6-(((1S)-1-(5-((4-methyl-1-piperazinyl)carbonyl)-3-phenyl-imidazo[1,2-a]pyridin-2-yl)ethyl)amino)-5-pyrimidinecarbonitrile

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Chemical Property of 4-Amino-6-(((1S)-1-(5-((4-methyl-1-piperazinyl)carbonyl)-3-phenyl-imidazo[1,2-a]pyridin-2-yl)ethyl)amino)-5-pyrimidinecarbonitrile

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Technology Process of 4-Amino-6-(((1S)-1-(5-((4-methyl-1-piperazinyl)carbonyl)-3-phenyl-imidazo[1,2-a]pyridin-2-yl)ethyl)amino)-5-pyrimidinecarbonitrile

There total 11 articles about 4-Amino-6-(((1S)-1-(5-((4-methyl-1-piperazinyl)carbonyl)-3-phenyl-imidazo[1,2-a]pyridin-2-yl)ethyl)amino)-5-pyrimidinecarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 109-01-3
1-methyl-piperazine

: 1338484-74-4
(S)-2-(1-((6-amino-5-cyanopyrimidin-4-yl)amino)ethyl)-3-phenylimidazo[1,2-a]pyridine-5-carboxylic acid

: 1338485-05-4
4-Amino-6-(((1S)-1-(5-((4-methyl-1-piperazinyl)carbonyl)-3-phenyl-imidazo[1,2-a]pyridin-2-yl)ethyl)amino)-5-pyrimidinecarbonitrile

Guidance literature:: With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

Reference yield:

: 36052-26-3
methyl 6-aminopyridine-2-carboxylate

: 1338485-05-4
4-Amino-6-(((1S)-1-(5-((4-methyl-1-piperazinyl)carbonyl)-3-phenyl-imidazo[1,2-a]pyridin-2-yl)ethyl)amino)-5-pyrimidinecarbonitrile

Guidance literature:: Multi-step reaction with 7 steps

1: ethanol / Reflux

2: N-iodo-succinimide / acetonitrile / 25 °C

3: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / acetonitrile; water / 25 - 95 °C / Inert atmosphere

4: trifluoroacetic acid; dimethylsulfide / 25 °C

5: N-ethyl-N,N-diisopropylamine / butan-1-ol / 25 - 110 °C

6: pyridine; lithium iodide / 100 °C

7: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 1 h / 20 °C

With pyridine; N-iodo-succinimide; dimethylsulfide; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; lithium iodide; sodium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; water; N,N-dimethyl-formamide; acetonitrile; butan-1-ol;

Reference yield:

: 1338484-58-4
(S)-methyl-2-(1-(((benzyloxy)carbonyl)amino)ethyl)imidazo[1,2-a]pyridine-5-carboxylate

: 1338485-05-4
4-Amino-6-(((1S)-1-(5-((4-methyl-1-piperazinyl)carbonyl)-3-phenyl-imidazo[1,2-a]pyridin-2-yl)ethyl)amino)-5-pyrimidinecarbonitrile

Guidance literature:: Multi-step reaction with 6 steps

1: N-iodo-succinimide / acetonitrile / 25 °C

2: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / acetonitrile; water / 25 - 95 °C / Inert atmosphere

3: trifluoroacetic acid; dimethylsulfide / 25 °C

4: N-ethyl-N,N-diisopropylamine / butan-1-ol / 25 - 110 °C

5: pyridine; lithium iodide / 100 °C

6: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 1 h / 20 °C

With pyridine; N-iodo-succinimide; dimethylsulfide; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; lithium iodide; sodium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In water; N,N-dimethyl-formamide; acetonitrile; butan-1-ol;