DL-LEUCINE-2-D1

Base Information

• Chemical Name: DL-LEUCINE-2-D1
• CAS No.: 282726-23-2
• Molecular Formula: C6H12 D N O2
• Molecular Weight: 132.18
• Mol file: 282726-23-2.mol

Synonyms:DL-LEUCINE-2-D1

Chemical Property of DL-LEUCINE-2-D1

Chemical Property:

• PSA: 63.32000
• LogP: 1.14470

Purity/Quality:

99% ^*data from raw suppliers

DL-Leucine-2-d1 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of DL-LEUCINE-2-D1

There total 4 articles about DL-LEUCINE-2-D1 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

L-leucine (61-90-5,21675-61-6,25248-98-0,70-45-1) → (R,S)-2-[2H1]-Leu (282726-23-2)

Guidance literature:

With deuteroacetic acid; salicylaldehyde; at 100 ℃; for 1h;

DOI:10.1002/(SICI)1099-1344(200004)43:5<449::AID-JLCR331>3.0.CO;2-0

Reference yield: 60.0%

LEUCINE (328-39-2,21675-61-6,25248-98-0,70-45-1) → (R,S)-2-[2H1]-Leu (282726-23-2)

Guidance literature:

LEUCINE; With salicylaldehyde; In tetradeuterioacetic acid; at 100 ℃; for 1h;

With water-d2; for 0.25h;

DOI:10.1021/jacs.1c11266

Reference yield:

4-methyl-2-oxopentanoic acid (816-66-0) → (R,S)-2-[2H1]-Leu (282726-23-2)

Guidance literature:

With water-d2; transaminase;

upstream raw materials:

L-leucine

sodium 4-methyl-2-oxovalerate

4-methyl-2-oxopentanoic acid

LEUCINE

Downstream raw materials:

(S)-α-deuterated leucine

(R)-α-deuterated leucine

(S)-Z-2-[2H₁]-Leu

(R)-Z-2-[2H₁]-Leu

Refernces

• 1、 Bach, Thorsten,Breitenlechner, Stefan,Gro?kopf, Johannes,Plaza, Manuel,Seitz, Antonia,Storch, Golo. "Photochemical Deracemization at sp3-Hybridized Carbon Centers via a Reversible Hydrogen Atom Transfer". supporting information. p. 21241 - 21245. Retrieved 2021/12/27.
• 2、 -. "Measurement of biosynthesis and breakdown rates of biological molecules that are inaccessible or not easily accessible to direct sampling, non-invasively, by label incorporation into metabolic derivatives and catabolitic products". Page 4. . Retrieved 2008/06/13.