(1R,2R)-2-(4-fluorophenyl)cyclopropanecarbonyl fluoride

Base Information

• Chemical Name: (1R,2R)-2-(4-fluorophenyl)cyclopropanecarbonyl fluoride
• CAS No.: 1414778-86-1
• Molecular Formula: C₁₀H₈F₂O
• Molecular Weight: 182.17
• Mol file: 1414778-86-1.mol

Synonyms:(1R,2R)-2-(4-fluorophenyl)cyclopropanecarbonyl fluoride

Chemical Property of (1R,2R)-2-(4-fluorophenyl)cyclopropanecarbonyl fluoride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R,2R)-2-(4-fluorophenyl)cyclopropanecarbonyl fluoride

There total 6 articles about (1R,2R)-2-(4-fluorophenyl)cyclopropanecarbonyl fluoride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(1R,2R)-2-(4-fluorophenyl)cyclopropanecarboxylic acid (161711-27-9,515179-19-8,879324-64-8) → (1R,2R)-2-(4-fluorophenyl)cyclopropanecarbonyl fluoride (1414778-86-1)

Guidance literature:

With diethylamino-sulfur trifluoride; In dichloromethane; at 20 ℃; for 1h; Inert atmosphere;

Reference yield:

2-(4-fluorophenyl)cyclopropanecarboxylic acid (515179-19-8,879324-64-8) → (1R,2R)-2-(4-fluorophenyl)cyclopropanecarbonyl fluoride (1414778-86-1)

Guidance literature:

Multi-step reaction with 2 steps

1: Chiralpak AD-H / ethanol; n-heptane / Resolution of racemate

2: diethylamino-sulfur trifluoride / dichloromethane / 1 h / 20 °C / Inert atmosphere

With diethylamino-sulfur trifluoride; In ethanol; n-heptane; dichloromethane;

Reference yield:

(1,2-trans)-2-(4'-fluorophenyl)-cyclopropanecarboxylic acid (515179-19-8,879324-64-8) → (1R,2R)-2-(4-fluorophenyl)cyclopropanecarbonyl fluoride (1414778-86-1)

Guidance literature:

Multi-step reaction with 2 steps

1: Chiralpak ADH / formic acid; ethanol; n-heptane / Resolution of racemate

2: diethylamino-sulfur trifluoride / dichloromethane / 1 h / 20 °C / Inert atmosphere

With diethylamino-sulfur trifluoride; In formic acid; ethanol; n-heptane; dichloromethane;

upstream raw materials:

2-(4-fluorophenyl)cyclopropanecarboxylic acid

(1,2-trans)-2-(4'-fluorophenyl)-cyclopropanecarboxylic acid

4-fluorocinnamic acid

(1R,2R)-2-(4-fluorophenyl)cyclopropanecarboxylic acid