1-(6-aminopyrimidin-4-yl)-4-(3,4-dichlorophenyl)piperidine-4-carbonitrile

Base Information

Chemical Name:1-(6-aminopyrimidin-4-yl)-4-(3,4-dichlorophenyl)piperidine-4-carbonitrile
CAS No.:1578262-43-7
Molecular Formula:C₁₆H₁₅Cl₂N₅
Molecular Weight:348.235
Hs Code.:

Synonyms:1-(6-aminopyrimidin-4-yl)-4-(3,4-dichlorophenyl)piperidine-4-carbonitrile

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Chemical Property of 1-(6-aminopyrimidin-4-yl)-4-(3,4-dichlorophenyl)piperidine-4-carbonitrile

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Technology Process of 1-(6-aminopyrimidin-4-yl)-4-(3,4-dichlorophenyl)piperidine-4-carbonitrile

There total 2 articles about 1-(6-aminopyrimidin-4-yl)-4-(3,4-dichlorophenyl)piperidine-4-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 5305-59-9
4-amino-6-chloropyrimidine

: 1071993-16-2
4-(3,4-dichlorophenyl)piperidine-4-carbonitrile hydrochloride

: 1578262-43-7
1-(6-aminopyrimidin-4-yl)-4-(3,4-dichlorophenyl)piperidine-4-carbonitrile

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 100 ℃; for 5h; Sealed tube;
DOI:10.1016/j.ejmech.2014.01.019

Reference yield:

: 1-benzyl-4-(3,4-dichlorophenyl)-piperidine-4-carbonitrile

: 1578262-43-7
1-(6-aminopyrimidin-4-yl)-4-(3,4-dichlorophenyl)piperidine-4-carbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: 2-Chloroethyl chloroformate / 1,2-dichloro-ethane; methanol / 5 h / 100 °C / Reflux

2: potassium carbonate / N,N-dimethyl-formamide / 5 h / 100 °C / Sealed tube

With potassium carbonate; 2-Chloroethyl chloroformate; In methanol; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2014.01.019

Reference yield: 62.0%

: 1578262-43-7
1-(6-aminopyrimidin-4-yl)-4-(3,4-dichlorophenyl)piperidine-4-carbonitrile

: 1578262-45-9
6-(4-(aminomethyl)-4-(3,4-dichlorophenyl)piperidin-1-yl)pyrimidin-4-amine

Guidance literature:: With aluminum (III) chloride; lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃;
DOI:10.1016/j.ejmech.2014.01.019