methyl 5-[2-azido-4-(ethoxycarbonyl)phenyl]-3-benzyl-2-(4-methoxybenzyl)-2,3-dihydro-1H-pyrazole-1-carboxylate

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Chemical Name:methyl 5-[2-azido-4-(ethoxycarbonyl)phenyl]-3-benzyl-2-(4-methoxybenzyl)-2,3-dihydro-1H-pyrazole-1-carboxylate
CAS No.:1434003-99-2
Molecular Formula:C₂₉H₂₉N₅O₅
Molecular Weight:527.58
Hs Code.:

Synonyms:methyl 5-[2-azido-4-(ethoxycarbonyl)phenyl]-3-benzyl-2-(4-methoxybenzyl)-2,3-dihydro-1H-pyrazole-1-carboxylate

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Chemical Property of methyl 5-[2-azido-4-(ethoxycarbonyl)phenyl]-3-benzyl-2-(4-methoxybenzyl)-2,3-dihydro-1H-pyrazole-1-carboxylate

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Technology Process of methyl 5-[2-azido-4-(ethoxycarbonyl)phenyl]-3-benzyl-2-(4-methoxybenzyl)-2,3-dihydro-1H-pyrazole-1-carboxylate

There total 2 articles about methyl 5-[2-azido-4-(ethoxycarbonyl)phenyl]-3-benzyl-2-(4-methoxybenzyl)-2,3-dihydro-1H-pyrazole-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 1383604-52-1
methyl 2-(4-methoxybenzyl)hydrazinecarboxylate

: 1434003-91-4
ethyl 3-azido-4-ethynylbenzoate

: 122-78-1
phenylacetaldehyde

: 1434003-99-2
methyl 5-[2-azido-4-(ethoxycarbonyl)phenyl]-3-benzyl-2-(4-methoxybenzyl)-2,3-dihydro-1H-pyrazole-1-carboxylate

Guidance literature:: With [AuCl(IPr)]; silver(I) triflimide; In 1,2-dichloro-ethane; at 50 ℃; Inert atmosphere;
DOI:10.1039/c3ob40223a

Reference yield:

: 1260650-82-5
C₁₁H₁₁NO₂

: 1434003-99-2
methyl 5-[2-azido-4-(ethoxycarbonyl)phenyl]-3-benzyl-2-(4-methoxybenzyl)-2,3-dihydro-1H-pyrazole-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium nitrite; sulfuric acid / water; acetonitrile; N,N-dimethyl-formamide / 0.5 h / 0 °C

1.2: 0.5 h / 0 - 20 °C

2.1: [AuCl(IPr)]; silver(I) triflimide / 1,2-dichloro-ethane / 50 °C / Inert atmosphere

With sulfuric acid; [AuCl(IPr)]; silver(I) triflimide; sodium nitrite; In water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1039/c3ob40223a