1,2,3,4,6,7,8,9-octahydro-1,6-dioxo-2-methyl-5-(2-methoxy-5-cyanophenoxy)-9-carbomethoxyisoquinoline

Base Information

Chemical Name:1,2,3,4,6,7,8,9-octahydro-1,6-dioxo-2-methyl-5-(2-methoxy-5-cyanophenoxy)-9-carbomethoxyisoquinoline
CAS No.:93758-09-9
Molecular Formula:C₂₀H₂₀N₂O₆
Molecular Weight:384.389
Hs Code.:

Synonyms:1,2,3,4,6,7,8,9-octahydro-1,6-dioxo-2-methyl-5-(2-methoxy-5-cyanophenoxy)-9-carbomethoxyisoquinoline

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Chemical Property of 1,2,3,4,6,7,8,9-octahydro-1,6-dioxo-2-methyl-5-(2-methoxy-5-cyanophenoxy)-9-carbomethoxyisoquinoline

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Technology Process of 1,2,3,4,6,7,8,9-octahydro-1,6-dioxo-2-methyl-5-(2-methoxy-5-cyanophenoxy)-9-carbomethoxyisoquinoline

There total 10 articles about 1,2,3,4,6,7,8,9-octahydro-1,6-dioxo-2-methyl-5-(2-methoxy-5-cyanophenoxy)-9-carbomethoxyisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 52805-46-6
2-methoxy-5-cyanophenol

: 93758-05-5
decahydro-1,6-dioxo-2-methyl-5,10-epoxy-9-carbomethoxyisoquinoline

: 93758-09-9
1,2,3,4,6,7,8,9-octahydro-1,6-dioxo-2-methyl-5-(2-methoxy-5-cyanophenoxy)-9-carbomethoxyisoquinoline

Guidance literature:: With potassium hydride; In tetrahydrofuran; 1.) RT, 3 h, 2.) reflux, 19 h;
DOI:10.1021/jo00202a014

Reference yield:

: 93758-45-3
Methyl 1-methyl-2,4-dioxopiperidine-3-carboxylate

: 93758-09-9
1,2,3,4,6,7,8,9-octahydro-1,6-dioxo-2-methyl-5-(2-methoxy-5-cyanophenoxy)-9-carbomethoxyisoquinoline

Guidance literature:: Multi-step reaction with 4 steps

2: acetic acid, water, sodium acetate / benzene / 1.5 h / Heating

3: 69 percent / 30percent H₂O₂, aq. NaOH / methanol / 2.5 h / 10 - 20 °C

4: 72 percent / KH / tetrahydrofuran / 1.) RT, 3 h, 2.) reflux, 19 h

With sodium hydroxide; water; dihydrogen peroxide; sodium acetate; potassium hydride; acetic acid; In tetrahydrofuran; methanol; benzene;
DOI:10.1021/jo00202a014

Reference yield:

: Methyl N-(3-methoxy-3-oxopropanoyl)-N-methyl-beta-alaninate

: 93758-09-9
1,2,3,4,6,7,8,9-octahydro-1,6-dioxo-2-methyl-5-(2-methoxy-5-cyanophenoxy)-9-carbomethoxyisoquinoline

Guidance literature:: Multi-step reaction with 5 steps

1: NaH / benzene; ethanol

3: acetic acid, water, sodium acetate / benzene / 1.5 h / Heating

4: 69 percent / 30percent H₂O₂, aq. NaOH / methanol / 2.5 h / 10 - 20 °C

5: 72 percent / KH / tetrahydrofuran / 1.) RT, 3 h, 2.) reflux, 19 h

With sodium hydroxide; water; dihydrogen peroxide; sodium acetate; potassium hydride; sodium hydride; acetic acid; In tetrahydrofuran; methanol; ethanol; benzene;
DOI:10.1021/jo00202a014