{6-[[2-(2-tert-butoxycarbonylamino-3-methyl-pentanoylamino)-3-phenyl-propionyl]-(1,1,4-trioxo-hexahydro-1λ⁶-thiopyran-3-yl)-amino]-hexyl}-carbamic acid tert-butyl ester

Base Information

• Chemical Name: {6-[[2-(2-tert-butoxycarbonylamino-3-methyl-pentanoylamino)-3-phenyl-propionyl]-(1,1,4-trioxo-hexahydro-1λ⁶-thiopyran-3-yl)-amino]-hexyl}-carbamic acid tert-butyl ester
• CAS No.: 868700-49-6
• Molecular Formula: C₃₆H₅₈N₄O₉S
• Molecular Weight: 722.944

Synonyms:{6-[[2-(2-tert-butoxycarbonylamino-3-methyl-pentanoylamino)-3-phenyl-propionyl]-(1,1,4-trioxo-hexahydro-1λ⁶-thiopyran-3-yl)-amino]-hexyl}-carbamic acid tert-butyl ester

Chemical Property of {6-[[2-(2-tert-butoxycarbonylamino-3-methyl-pentanoylamino)-3-phenyl-propionyl]-(1,1,4-trioxo-hexahydro-1λ⁶-thiopyran-3-yl)-amino]-hexyl}-carbamic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of {6-[[2-(2-tert-butoxycarbonylamino-3-methyl-pentanoylamino)-3-phenyl-propionyl]-(1,1,4-trioxo-hexahydro-1λ⁶-thiopyran-3-yl)-amino]-hexyl}-carbamic acid tert-butyl ester

There total 15 articles about {6-[[2-(2-tert-butoxycarbonylamino-3-methyl-pentanoylamino)-3-phenyl-propionyl]-(1,1,4-trioxo-hexahydro-1λ⁶-thiopyran-3-yl)-amino]-hexyl}-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

{6-[[2-(2-tert-butoxycarbonylamino-3-methyl-pentanoylamino)-3-phenyl-propionyl]-(4-hydroxy-1,1-dioxo-hexahydro-1λ6-thiopyran-3-yl)-amino]-hexyl}-carbamic acid tert-butyl ester → {6-[[2-(2-tert-butoxycarbonylamino-3-methyl-pentanoylamino)-3-phenyl-propionyl]-(1,1,4-trioxo-hexahydro-1λ6-thiopyran-3-yl)-amino]-hexyl}-carbamic acid tert-butyl ester (868700-49-6)

Guidance literature:

With Dess-Martin periodane; In dichloromethane; at 20 ℃; for 12h;

DOI:10.1021/jo0508954

Reference yield:

tert-Butyl-((3R,4R)-3-isocyanato-tetrahydro-thiopyran-4-yloxy)-dimethyl-silane → {6-[[2-(2-tert-butoxycarbonylamino-3-methyl-pentanoylamino)-3-phenyl-propionyl]-(1,1,4-trioxo-hexahydro-1λ6-thiopyran-3-yl)-amino]-hexyl}-carbamic acid tert-butyl ester (868700-49-6)

Guidance literature:

Multi-step reaction with 11 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.08 h / 0 °C

1.2: 3.60 g / tetrahydrofuran; hexane / 0.5 h / 0 - 20 °C

2.1: 74 percent / NaIO₄; KMnO₄; NaHCO₃ / acetone; H₂O / 6 h / 20 °C

3.1: 100 percent / H₂ / Pd/C / methanol / 5 h / 20 °C / 760 Torr

4.1: 1,2-dichloro-ethane / 0.42 h

5.1: 387 mg / sodium triacetoxyborohydride / 1,2-dichloro-ethane / 5 h / 20 °C

6.1: acetonitrile / 2 h / 20 °C

7.1: 230 mg / tetrabutylammonium fluoride / acetonitrile / 4 h / 60 °C

8.1: piperidine / dimethylformamide / 1 h / 20 °C

9.1: 80 percent / HBTU; N,N-diisopropylethylamine / dimethylformamide / 2 h / 20 °C

10.1: tetrabutylammonium fluoride / tetrahydrofuran / 0.5 h / 20 °C

11.1: 98 mg / Dess-Martin periodinane / CH₂Cl₂ / 12 h / 20 °C

With piperidine; potassium permanganate; sodium periodate; n-butyllithium; tetrabutyl ammonium fluoride; hydrogen; sodium tris(acetoxy)borohydride; sodium hydrogencarbonate; Dess-Martin periodane; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; hexane; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetone; acetonitrile;

DOI:10.1021/jo0508954

Reference yield:

(3S,4R)-4-(tert-Butyl-dimethyl-silanyloxy)-tetrahydro-thiopyran-3-carboxylic acid → {6-[[2-(2-tert-butoxycarbonylamino-3-methyl-pentanoylamino)-3-phenyl-propionyl]-(1,1,4-trioxo-hexahydro-1λ6-thiopyran-3-yl)-amino]-hexyl}-carbamic acid tert-butyl ester (868700-49-6)

Guidance literature:

Multi-step reaction with 12 steps

1.1: diphenylphosphoryl azide; N,N-diisopropylethylamine / toluene / 4 h / 60 °C

2.1: n-butyllithium / tetrahydrofuran; hexane / 0.08 h / 0 °C

2.2: 3.60 g / tetrahydrofuran; hexane / 0.5 h / 0 - 20 °C

3.1: 74 percent / NaIO₄; KMnO₄; NaHCO₃ / acetone; H₂O / 6 h / 20 °C

4.1: 100 percent / H₂ / Pd/C / methanol / 5 h / 20 °C / 760 Torr

5.1: 1,2-dichloro-ethane / 0.42 h

6.1: 387 mg / sodium triacetoxyborohydride / 1,2-dichloro-ethane / 5 h / 20 °C

7.1: acetonitrile / 2 h / 20 °C

8.1: 230 mg / tetrabutylammonium fluoride / acetonitrile / 4 h / 60 °C

9.1: piperidine / dimethylformamide / 1 h / 20 °C

10.1: 80 percent / HBTU; N,N-diisopropylethylamine / dimethylformamide / 2 h / 20 °C

11.1: tetrabutylammonium fluoride / tetrahydrofuran / 0.5 h / 20 °C

12.1: 98 mg / Dess-Martin periodinane / CH₂Cl₂ / 12 h / 20 °C

With piperidine; potassium permanganate; sodium periodate; n-butyllithium; diphenylphosphoranyl azide; tetrabutyl ammonium fluoride; hydrogen; sodium tris(acetoxy)borohydride; sodium hydrogencarbonate; Dess-Martin periodane; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; hexane; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetone; toluene; acetonitrile; 1.1: Curtius rearrangement;

DOI:10.1021/jo0508954

upstream raw materials:

(6-{[2-(2-tert-butoxycarbonylamino-3-methyl-pentanoylamino)-3-phenyl-propionyl]-[4-(tert-butyl-dimethyl-silanyloxy)-1,1-dioxo-hexahydro-1λ⁶-thiopyran-3-yl]-amino}-hexyl)-carbamic acid tert-butyl ester

(6-{[4-(tert-butyl-dimethyl-silanyloxy)-1,1-dioxo-hexahydro-1λ⁶-thiopyran-3-yl]-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-phenyl-propionyl]-amino}-hexyl)-carbamic acid tert-butyl ester

3-methoxycarbonyltetrahydropyran-4-one

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 868700-49-6 {6-[[2-(2-tert-butoxycarbonylamino-3-methyl-pentanoylamino)-3-phenyl-propionyl]-(1,1,4-trioxo-hexahydro-1λ⁶-thiopyran-3-yl)-amino]-hexyl}-carbamic acid tert-butyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send