methyl 6?chloro?1?(4?chlorophenyl)?4?oxo?1,4?dihydrothieno[2,3?c]pyridazine?3?carboxylate

Base Information

Chemical Name:methyl 6?chloro?1?(4?chlorophenyl)?4?oxo?1,4?dihydrothieno[2,3?c]pyridazine?3?carboxylate
CAS No.:190207-56-8
Molecular Formula:C₁₄H₈Cl₂N₂O₃S
Molecular Weight:355.201
Hs Code.:

Synonyms:methyl 6?chloro?1?(4?chlorophenyl)?4?oxo?1,4?dihydrothieno[2,3?c]pyridazine?3?carboxylate

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Chemical Property of methyl 6?chloro?1?(4?chlorophenyl)?4?oxo?1,4?dihydrothieno[2,3?c]pyridazine?3?carboxylate

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Technology Process of methyl 6?chloro?1?(4?chlorophenyl)?4?oxo?1,4?dihydrothieno[2,3?c]pyridazine?3?carboxylate

There total 4 articles about methyl 6?chloro?1?(4?chlorophenyl)?4?oxo?1,4?dihydrothieno[2,3?c]pyridazine?3?carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 2-[(4-Chloro-phenyl)-hydrazono]-3-(2,5-dichloro-thiophen-3-yl)-3-oxo-propionic acid methyl ester

: 190207-56-8
methyl 6?chloro?1?(4?chlorophenyl)?4?oxo?1,4?dihydrothieno[2,3?c]pyridazine?3?carboxylate

Guidance literature:: With sodium hydride; In tetrahydrofuran; 1) 23 deg C, 2) 60 deg C to 63 deg C;
DOI:10.1002/prac.19973390150

Reference yield: 60.0%

: C₁₄H₉Cl₃N₂O₃S

: 190207-56-8
methyl 6?chloro?1?(4?chlorophenyl)?4?oxo?1,4?dihydrothieno[2,3?c]pyridazine?3?carboxylate

Guidance literature:: With sodium hydride; In tetrahydrofuran; at 15 ℃;
DOI:10.1016/j.tetlet.2015.11.068

Reference yield:

: 36157-40-1
3-acetyl-2,5-dichlorothiophene

: 190207-56-8
methyl 6?chloro?1?(4?chlorophenyl)?4?oxo?1,4?dihydrothieno[2,3?c]pyridazine?3?carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 58 percent / NaH / 84 - 86 °C

2: 1) aq. NaNO₂, 6 M HCl, 2) pyridine / 1) 0 deg C to 3 deg C, 2) H₂O, 0 deg C to 4 deg C

3: 60 percent / NaH / tetrahydrofuran / 1) 23 deg C, 2) 60 deg C to 63 deg C

With pyridine; hydrogenchloride; sodium hydride; sodium nitrite; In tetrahydrofuran;
DOI:10.1002/prac.19973390150