4,5-bis<4-(dimethylamino)phenyl>-2-<<5-<<2-(2-methoxyethoxy)ethyl>amino>pentyl>thio>-1H-imidazole

Base Information

Chemical Name:4,5-bis<4-(dimethylamino)phenyl>-2-<<5-<<2-(2-methoxyethoxy)ethyl>amino>pentyl>thio>-1H-imidazole
CAS No.:162933-18-8
Molecular Formula:C₂₉H₄₃N₅O₂S
Molecular Weight:525.759
Hs Code.:

Synonyms:4,5-bis<4-(dimethylamino)phenyl>-2-<<5-<<2-(2-methoxyethoxy)ethyl>amino>pentyl>thio>-1H-imidazole

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Chemical Property of 4,5-bis<4-(dimethylamino)phenyl>-2-<<5-<<2-(2-methoxyethoxy)ethyl>amino>pentyl>thio>-1H-imidazole

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Technology Process of 4,5-bis<4-(dimethylamino)phenyl>-2-<<5-<<2-(2-methoxyethoxy)ethyl>amino>pentyl>thio>-1H-imidazole

There total 8 articles about 4,5-bis<4-(dimethylamino)phenyl>-2-<<5-<<2-(2-methoxyethoxy)ethyl>amino>pentyl>thio>-1H-imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 162933-14-4
N-<2-(2-methoxymethoxy)ethyl>5-<<4,5-bis(4-dimethylamino)-1H-imidazol-2-yl>thio>pentanamide

: 162933-18-8
4,5-bis<4-(dimethylamino)phenyl>-2-<<5-<<2-(2-methoxyethoxy)ethyl>amino>pentyl>thio>-1H-imidazole

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; for 18h; Heating;
DOI:10.1021/jm00007a004

Reference yield:

: 111-77-3,95507-80-5
2-(2-methoxyethoxy)ethyl alcohol

: 162933-18-8
4,5-bis<4-(dimethylamino)phenyl>-2-<<5-<<2-(2-methoxyethoxy)ethyl>amino>pentyl>thio>-1H-imidazole

Guidance literature:: Multi-step reaction with 6 steps

1: PBr₃, pyridine / benzene / 56 h

2: sodium azide, NaI / dimethylformamide / 18 h / 60 °C

3: 1.) Ph₃P, 2.) H₂O / 1.) THF, RT, 10 h, 2.) THF, RT, 24 h

4: aq. K₂CO₃ / tetrahydrofuran / 4 h / Ambient temperature

5: 79 percent / K₂CO₃, tetra-n-butylammonium iodide / tetrahydrofuran / 2 h / Heating

6: 99 percent / LiAlH₄ / tetrahydrofuran / 18 h / Heating

With pyridine; lithium aluminium tetrahydride; sodium azide; water; phosphorus tribromide; tetra-(n-butyl)ammonium iodide; potassium carbonate; triphenylphosphine; sodium iodide; In tetrahydrofuran; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jm00007a004

Reference yield:

: 54149-17-6,92450-98-1
2-bromoethyl 2-methoxyethyl ether

: 162933-18-8
4,5-bis<4-(dimethylamino)phenyl>-2-<<5-<<2-(2-methoxyethoxy)ethyl>amino>pentyl>thio>-1H-imidazole

Guidance literature:: Multi-step reaction with 5 steps

1: sodium azide, NaI / dimethylformamide / 18 h / 60 °C

2: 1.) Ph₃P, 2.) H₂O / 1.) THF, RT, 10 h, 2.) THF, RT, 24 h

3: aq. K₂CO₃ / tetrahydrofuran / 4 h / Ambient temperature

4: 79 percent / K₂CO₃, tetra-n-butylammonium iodide / tetrahydrofuran / 2 h / Heating

5: 99 percent / LiAlH₄ / tetrahydrofuran / 18 h / Heating

With lithium aluminium tetrahydride; sodium azide; water; tetra-(n-butyl)ammonium iodide; potassium carbonate; triphenylphosphine; sodium iodide; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm00007a004