4,5-bis<4-(dimethylamino)phenyl>-2-<<5-<<2-(2-methoxyethoxy)ethyl>amino>pentyl>thio>-1H-imidazole

Base Information

• Chemical Name: 4,5-bis<4-(dimethylamino)phenyl>-2-<<5-<<2-(2-methoxyethoxy)ethyl>amino>pentyl>thio>-1H-imidazole
• CAS No.: 162933-18-8
• Molecular Formula: C₂₉H₄₃N₅O₂S
• Molecular Weight: 525.759
• Mol file: 162933-18-8.mol

Synonyms:4,5-bis<4-(dimethylamino)phenyl>-2-<<5-<<2-(2-methoxyethoxy)ethyl>amino>pentyl>thio>-1H-imidazole

Chemical Property of 4,5-bis<4-(dimethylamino)phenyl>-2-<<5-<<2-(2-methoxyethoxy)ethyl>amino>pentyl>thio>-1H-imidazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4,5-bis<4-(dimethylamino)phenyl>-2-<<5-<<2-(2-methoxyethoxy)ethyl>amino>pentyl>thio>-1H-imidazole

There total 8 articles about 4,5-bis<4-(dimethylamino)phenyl>-2-<<5-<<2-(2-methoxyethoxy)ethyl>amino>pentyl>thio>-1H-imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

N-<2-(2-methoxymethoxy)ethyl>5-<<4,5-bis(4-dimethylamino)-1H-imidazol-2-yl>thio>pentanamide (162933-14-4) → 4,5-bis<4-(dimethylamino)phenyl>-2-<<5-<<2-(2-methoxyethoxy)ethyl>amino>pentyl>thio>-1H-imidazole (162933-18-8)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 18h; Heating;

DOI:10.1021/jm00007a004

Reference yield:

2-(2-methoxyethoxy)ethyl alcohol (111-77-3,95507-80-5) → 4,5-bis<4-(dimethylamino)phenyl>-2-<<5-<<2-(2-methoxyethoxy)ethyl>amino>pentyl>thio>-1H-imidazole (162933-18-8)

Guidance literature:

Multi-step reaction with 6 steps

1: PBr₃, pyridine / benzene / 56 h

2: sodium azide, NaI / dimethylformamide / 18 h / 60 °C

3: 1.) Ph₃P, 2.) H₂O / 1.) THF, RT, 10 h, 2.) THF, RT, 24 h

4: aq. K₂CO₃ / tetrahydrofuran / 4 h / Ambient temperature

5: 79 percent / K₂CO₃, tetra-n-butylammonium iodide / tetrahydrofuran / 2 h / Heating

6: 99 percent / LiAlH₄ / tetrahydrofuran / 18 h / Heating

With pyridine; lithium aluminium tetrahydride; sodium azide; water; phosphorus tribromide; tetra-(n-butyl)ammonium iodide; potassium carbonate; triphenylphosphine; sodium iodide; In tetrahydrofuran; N,N-dimethyl-formamide; benzene;

DOI:10.1021/jm00007a004

Reference yield:

2-bromoethyl 2-methoxyethyl ether (54149-17-6,92450-98-1) → 4,5-bis<4-(dimethylamino)phenyl>-2-<<5-<<2-(2-methoxyethoxy)ethyl>amino>pentyl>thio>-1H-imidazole (162933-18-8)

Guidance literature:

Multi-step reaction with 5 steps

1: sodium azide, NaI / dimethylformamide / 18 h / 60 °C

2: 1.) Ph₃P, 2.) H₂O / 1.) THF, RT, 10 h, 2.) THF, RT, 24 h

3: aq. K₂CO₃ / tetrahydrofuran / 4 h / Ambient temperature

4: 79 percent / K₂CO₃, tetra-n-butylammonium iodide / tetrahydrofuran / 2 h / Heating

5: 99 percent / LiAlH₄ / tetrahydrofuran / 18 h / Heating

With lithium aluminium tetrahydride; sodium azide; water; tetra-(n-butyl)ammonium iodide; potassium carbonate; triphenylphosphine; sodium iodide; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1021/jm00007a004

upstream raw materials:

N-<2-(2-methoxymethoxy)ethyl>5-<<4,5-bis(4-dimethylamino)-1H-imidazol-2-yl>thio>pentanamide

2-(2-methoxyethoxy)ethyl alcohol

2-bromoethyl 2-methoxyethyl ether

2-(2-methoxyethoxy)ethanamine