(2R,3S,4R,5S)-6-benzyloxycarbonyl-2-benzyloxymethyl-3,4-isopropylidenedioxy-1-oxa-6,8-diazaspiro[4.4]nonan-7-one

Base Information

Chemical Name:(2R,3S,4R,5S)-6-benzyloxycarbonyl-2-benzyloxymethyl-3,4-isopropylidenedioxy-1-oxa-6,8-diazaspiro[4.4]nonan-7-one
CAS No.:145122-02-7
Molecular Formula:C₂₅H₂₈N₂O₇
Molecular Weight:468.507
Hs Code.:

Synonyms:(2R,3S,4R,5S)-6-benzyloxycarbonyl-2-benzyloxymethyl-3,4-isopropylidenedioxy-1-oxa-6,8-diazaspiro[4.4]nonan-7-one

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Chemical Property of (2R,3S,4R,5S)-6-benzyloxycarbonyl-2-benzyloxymethyl-3,4-isopropylidenedioxy-1-oxa-6,8-diazaspiro[4.4]nonan-7-one

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Technology Process of (2R,3S,4R,5S)-6-benzyloxycarbonyl-2-benzyloxymethyl-3,4-isopropylidenedioxy-1-oxa-6,8-diazaspiro[4.4]nonan-7-one

There total 5 articles about (2R,3S,4R,5S)-6-benzyloxycarbonyl-2-benzyloxymethyl-3,4-isopropylidenedioxy-1-oxa-6,8-diazaspiro[4.4]nonan-7-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 145122-01-6
(2R,3S,4R,5S)-6-benzyloxycarbonyl-2-benzyloxymethyl-3,4-isopropylidenedioxy-8-(4-methoxybenzyl)-1-oxa-6,8-diazaspiro[4.4]nonan-7-one

: 145122-02-7
(2R,3S,4R,5S)-6-benzyloxycarbonyl-2-benzyloxymethyl-3,4-isopropylidenedioxy-1-oxa-6,8-diazaspiro[4.4]nonan-7-one

Guidance literature:: With ammonium cerium(IV) nitrate; In water; acetonitrile; for 0.333333h; Ambient temperature;

Reference yield:

: 133909-08-7
(2R,3S,4R,5S)-2-benzyloxymethyl-8-(4-methoxybenzyl)-6-benzyloxycarbonyl-3,4-dihydroxy-1-oxa-6,8-diazaspiro<4,4>nonane-7,9-dione

: 145122-02-7
(2R,3S,4R,5S)-6-benzyloxycarbonyl-2-benzyloxymethyl-3,4-isopropylidenedioxy-1-oxa-6,8-diazaspiro[4.4]nonan-7-one

Guidance literature:: Multi-step reaction with 5 steps

1: 83 percent / p-TsOH*H₂O / dioxane / 0.83 h / 50 °C

2: 91 percent / NaBH₄ / methanol / 0.67 h / Ambient temperature

3: n-Bu₃P / CH₂Cl₂ / 28 h / Ambient temperature

4: 75 percent / n-Bu₃SnH, AIBN / toluene / 1 h / 100 °C

5: 51 percent / ceric ammonium nitrate / acetonitrile; H₂O / 0.33 h / Ambient temperature

With sodium tetrahydroborate; ammonium cerium(IV) nitrate; 2,2'-azobis(isobutyronitrile); tributylphosphine; tri-n-butyl-tin hydride; toluene-4-sulfonic acid; In 1,4-dioxane; methanol; dichloromethane; water; toluene; acetonitrile;

Reference yield:

: 130508-98-4
(2R,3S,4R,5S)-6-benzyloxycarbonyl-2-benzyloxymethyl-3,4-isopropylidenedioxy-8-(4-methoxybenzyl)-1-oxa-6,8-diazaspiro[4.4]nonane-7,9-dione

: 145122-02-7
(2R,3S,4R,5S)-6-benzyloxycarbonyl-2-benzyloxymethyl-3,4-isopropylidenedioxy-1-oxa-6,8-diazaspiro[4.4]nonan-7-one

Guidance literature:: Multi-step reaction with 4 steps

1: 91 percent / NaBH₄ / methanol / 0.67 h / Ambient temperature

2: n-Bu₃P / CH₂Cl₂ / 28 h / Ambient temperature

3: 75 percent / n-Bu₃SnH, AIBN / toluene / 1 h / 100 °C

4: 51 percent / ceric ammonium nitrate / acetonitrile; H₂O / 0.33 h / Ambient temperature

With sodium tetrahydroborate; ammonium cerium(IV) nitrate; 2,2'-azobis(isobutyronitrile); tributylphosphine; tri-n-butyl-tin hydride; In methanol; dichloromethane; water; toluene; acetonitrile;