N⁶-benzoyl-9-(2-deoxy-3-O-(triisopropylsilyl)-β-D-erythrofuranosyl)-8-(hydroxymethyl)adenine

Base Information

• Chemical Name: N⁶-benzoyl-9-(2-deoxy-3-O-(triisopropylsilyl)-β-D-erythrofuranosyl)-8-(hydroxymethyl)adenine
• CAS No.: 355819-72-6
• Molecular Formula: C₂₆H₃₇N₅O₄Si
• Molecular Weight: 511.696
• Mol file: 355819-72-6.mol

Synonyms:N⁶-benzoyl-9-(2-deoxy-3-O-(triisopropylsilyl)-β-D-erythrofuranosyl)-8-(hydroxymethyl)adenine

Chemical Property of N⁶-benzoyl-9-(2-deoxy-3-O-(triisopropylsilyl)-β-D-erythrofuranosyl)-8-(hydroxymethyl)adenine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N⁶-benzoyl-9-(2-deoxy-3-O-(triisopropylsilyl)-β-D-erythrofuranosyl)-8-(hydroxymethyl)adenine

There total 1 articles about N⁶-benzoyl-9-(2-deoxy-3-O-(triisopropylsilyl)-β-D-erythrofuranosyl)-8-(hydroxymethyl)adenine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

N,N-dimethyl-formamide (68-12-2,33513-42-7) + N6-benzoyl-9-[2'-deoxy-3'-O-(triisopropylsilyl)-β-D-glycero-tetrofuranosyl]adenine (355819-60-2) → N6-benzoyl-9-(2-deoxy-3-O-(triisopropylsilyl)-β-D-erythrofuranosyl)-8-(hydroxymethyl)adenine (355819-72-6)

Guidance literature:

Multistep reaction;

DOI:10.1002/1522-2675(20010516)84:5<1000::AID-HLCA1000>3.0.CO;2-S

Reference yield: 89.0%

4,4'-dimethoxytrityl chloride (40615-36-9) + N6-benzoyl-9-(2-deoxy-3-O-(triisopropylsilyl)-β-D-erythrofuranosyl)-8-(hydroxymethyl)adenine (355819-72-6) → N6-benzoyl-9-[2'-deoxy-3'-O-(triisopropylsilyl)-β-D-glycero-tetrofuranosyl]-8-[(4,4'-dimethoxytrityloxy)methyl]adenine (355819-79-3)

Guidance literature:

With dmap; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 23 ℃; for 16h;

DOI:10.1002/1522-2675(20010516)84:5<1000::AID-HLCA1000>3.0.CO;2-S

Reference yield: 80.0%

N6-benzoyl-9-(2-deoxy-3-O-(triisopropylsilyl)-β-D-erythrofuranosyl)-8-(hydroxymethyl)adenine (355819-72-6) → N6-benzoyl-9-(2-deoxy-β-D-erythrofuranosyl)-8-(hydroxymethyl)adenine

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 23 ℃; for 3h;

DOI:10.1002/1522-2675(20010516)84:5<1000::AID-HLCA1000>3.0.CO;2-S

upstream raw materials:

N,N-dimethyl-formamide

N⁶-benzoyl-9-[2'-deoxy-3'-O-(triisopropylsilyl)-β-D-glycero-tetrofuranosyl]adenine

Downstream raw materials:

N⁶-benzoyl-9-[2'-deoxy-3'-O-(triisopropylsilyl)-β-D-glycero-tetrofuranosyl]-8-[(4,4'-dimethoxytrityloxy)methyl]adenine

N⁶-benzoyl-9-[2'-deoxy-β-D-glycero-tetrofuranosyl]-8-[(4,4'-dimethoxytrityloxy)methyl]adenine