4-((2-(difluoromethoxy)-3-methoxy-6-(1-oxo-1,3-dihydroisobenzofuran-5-yl)phenoxy)methyl)benzenamide

Base Information

Chemical Name:4-((2-(difluoromethoxy)-3-methoxy-6-(1-oxo-1,3-dihydroisobenzofuran-5-yl)phenoxy)methyl)benzenamide
CAS No.:1345880-44-5
Molecular Formula:C₂₄H₁₉F₂NO₆
Molecular Weight:455.415
Hs Code.:

Synonyms:4-((2-(difluoromethoxy)-3-methoxy-6-(1-oxo-1,3-dihydroisobenzofuran-5-yl)phenoxy)methyl)benzenamide

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Chemical Property of 4-((2-(difluoromethoxy)-3-methoxy-6-(1-oxo-1,3-dihydroisobenzofuran-5-yl)phenoxy)methyl)benzenamide

Chemical Property:

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Technology Process of 4-((2-(difluoromethoxy)-3-methoxy-6-(1-oxo-1,3-dihydroisobenzofuran-5-yl)phenoxy)methyl)benzenamide

There total 8 articles about 4-((2-(difluoromethoxy)-3-methoxy-6-(1-oxo-1,3-dihydroisobenzofuran-5-yl)phenoxy)methyl)benzenamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.9%

: 1345882-25-8
5-(3-(difluoromethoxy)-2-hydroxy-4-methoxyphenyl)isobenzofuran-1(3H)-one

: 58914-40-2
4-(bromomethyl)benzamide

: 1345880-44-5
4-((2-(difluoromethoxy)-3-methoxy-6-(1-oxo-1,3-dihydroisobenzofuran-5-yl)phenoxy)methyl)benzenamide

Guidance literature:: With potassium carbonate; In acetonitrile; at 70 ℃; for 16h;

Reference yield:

: 64169-34-2
5-bromophthalide

: 1345880-44-5
4-((2-(difluoromethoxy)-3-methoxy-6-(1-oxo-1,3-dihydroisobenzofuran-5-yl)phenoxy)methyl)benzenamide

Guidance literature:: Multi-step reaction with 4 steps

1: potassium acetate / bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / 16 h / 50 - 80 °C / Inert atmosphere

2: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 4 h / 80 °C / Inert atmosphere

3: hydrogenchloride; water / methanol / 1 h / 50 °C

4: potassium carbonate / acetonitrile / 16 h / 70 °C

With hydrogenchloride; water; potassium acetate; potassium carbonate; caesium carbonate; bis-triphenylphosphine-palladium(II) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; methanol; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 934-00-9
3-methocycatechol

: 1345880-44-5
4-((2-(difluoromethoxy)-3-methoxy-6-(1-oxo-1,3-dihydroisobenzofuran-5-yl)phenoxy)methyl)benzenamide

Guidance literature:: Multi-step reaction with 6 steps

1: N-Bromosuccinimide / tetrachloromethane / 2 h / 20 °C

2: potassium carbonate / acetone / 2 h / 20 °C

3: potassium carbonate / N,N-dimethyl-formamide / 2 h / 80 °C

4: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 4 h / 80 °C / Inert atmosphere

5: hydrogenchloride; water / methanol / 1 h / 50 °C

6: potassium carbonate / acetonitrile / 16 h / 70 °C

With hydrogenchloride; N-Bromosuccinimide; water; potassium carbonate; caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; tetrachloromethane; N,N-dimethyl-formamide; acetone; acetonitrile;