1-<4-(tert-butyloxycarbonyl)phenyl>-4-piperidinone

Base Information

• Chemical Name: 1-<4-(tert-butyloxycarbonyl)phenyl>-4-piperidinone
• CAS No.: 161181-86-8
• Molecular Formula: C₂₁H₂₆N₂O₄
• Molecular Weight: 370.448
• Mol file: 161181-86-8.mol

Synonyms:1-<4-(tert-butyloxycarbonyl)phenyl>-4-piperidinone

Chemical Property of 1-<4-(tert-butyloxycarbonyl)phenyl>-4-piperidinone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-<4-(tert-butyloxycarbonyl)phenyl>-4-piperidinone

There total 1 articles about 1-<4-(tert-butyloxycarbonyl)phenyl>-4-piperidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

1-<4-(tert-butyloxycarbonyl)phenyl>-4-piperidinone (95017-68-8) + ethyl 2-cyanoacetate (105-56-6) → 1-<4-(tert-butyloxycarbonyl)phenyl>-4-piperidinone (161181-86-8)

Guidance literature:

With ammonium acetate; acetic acid; In benzene; for 6h; Heating;

DOI:10.1002/jhet.5570310522

Reference yield: 100.0%

1-<4-(tert-butyloxycarbonyl)phenyl>-4-piperidinone (161181-86-8) → 1-<4-(tert-butyloxycarbonyl)phenyl>-4-piperidine (161181-87-9)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; for 2h; under 2689.2 Torr;

DOI:10.1002/jhet.5570310522

Reference yield:

1-<4-(tert-butyloxycarbonyl)phenyl>-4-piperidinone (161181-86-8) → 4-(2,4-diamino-6(5H)-oxopyrimidin-5-yl)-1-(4-carboxyphenyl)piperidine

Guidance literature:

Multi-step reaction with 3 steps

1: 100 percent / H₂ / 10percent Pd/C / ethanol / 2 h / 2689.2 Torr

2: 1.) C₂H₅ONa / 1.) EtOH, reflux, 30 min, 2.) EtOH, reflux, 23 h

3: 74 percent / trifluoroacetic acid / 2 h / 0 °C

With hydrogen; sodium ethanolate; trifluoroacetic acid; palladium on activated charcoal; In ethanol;

DOI:10.1002/jhet.5570310522

upstream raw materials:

1-<4-(tert-butyloxycarbonyl)phenyl>-4-piperidinone

ethyl 2-cyanoacetate

Downstream raw materials:

1-<4-(tert-butyloxycarbonyl)phenyl>-4-piperidine