4-amino-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-(ptolyl)pyrimidin-2(1H)-one

Base Information

• Chemical Name: 4-amino-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-(ptolyl)pyrimidin-2(1H)-one
• CAS No.: 136136-41-9
• Molecular Formula: C₁₆H₁₉N₃O₄
• Molecular Weight: 317.345

Synonyms:4-amino-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-(ptolyl)pyrimidin-2(1H)-one

Chemical Property of 4-amino-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-(ptolyl)pyrimidin-2(1H)-one

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Technology Process of 4-amino-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-(ptolyl)pyrimidin-2(1H)-one

There total 2 articles about 4-amino-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-(ptolyl)pyrimidin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

4-methylphenylboronic acid (5720-05-8) + 5-Iodo-2'-deoxycytidine (611-53-0) → 4-amino-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-(ptolyl)pyrimidin-2(1H)-one (136136-41-9)

Guidance literature:

With C₃₀H₂₄Cl₂N₂O₁₀Pd₂S₂^(2-)*2Na⁽¹⁺⁾; triethylamine; In water; at 60 ℃; for 24h; Inert atmosphere; Schlenk technique;

DOI:10.1021/acs.organomet.0c00580

Reference yield:

4-tolyl iodide (624-31-7) + 5-(chloromercuri)-2'-deoxycytidine (65523-09-3) → 4-amino-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-(ptolyl)pyrimidin-2(1H)-one (136136-41-9)

Guidance literature:

With lithium pentachloropalladate; Yield given. Multistep reaction; 1.) CH₃OH, RT, 1 h, 2.) RT, 72 h;

upstream raw materials:

4-tolyl iodide

5-(chloromercuri)-2'-deoxycytidine

4-methylphenylboronic acid

5-Iodo-2'-deoxycytidine

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