1-(2,6-difluorobenzyl)-3-(2-oxoethyl)-5-(3-methoxyphenyl)-6-methyluracil

Base Information

Chemical Name:1-(2,6-difluorobenzyl)-3-(2-oxoethyl)-5-(3-methoxyphenyl)-6-methyluracil
CAS No.:552291-17-5
Molecular Formula:C₂₁H₁₈F₂N₂O₄
Molecular Weight:400.382
Hs Code.:

Synonyms:1-(2,6-difluorobenzyl)-3-(2-oxoethyl)-5-(3-methoxyphenyl)-6-methyluracil

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Chemical Property of 1-(2,6-difluorobenzyl)-3-(2-oxoethyl)-5-(3-methoxyphenyl)-6-methyluracil

Chemical Property:

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Technology Process of 1-(2,6-difluorobenzyl)-3-(2-oxoethyl)-5-(3-methoxyphenyl)-6-methyluracil

There total 5 articles about 1-(2,6-difluorobenzyl)-3-(2-oxoethyl)-5-(3-methoxyphenyl)-6-methyluracil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 10365-98-7,1107579-37-2
3-methoxyphenylboronic acid

: 352303-62-9
1-(2,6-difluorobenzyl)-3-(2-oxoethyl)-5-bromo-6-methyluracil

: 552291-17-5
1-(2,6-difluorobenzyl)-3-(2-oxoethyl)-5-(3-methoxyphenyl)-6-methyluracil

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In toluene; at 90 ℃; for 14h;
DOI:10.1021/jm034041s

Reference yield:

: 59857-37-3
N₃-monoallyl-6-methyluracil

: 552291-17-5
1-(2,6-difluorobenzyl)-3-(2-oxoethyl)-5-(3-methoxyphenyl)-6-methyluracil

Guidance literature:: Multi-step reaction with 4 steps

1: 59 percent / TBAF / tetrahydrofuran; dimethylformamide / 48 h / 20 °C

2: aq. NaIO₄; OsO₄ / tetrahydrofuran / 3 h / 20 °C

3: 1.1 g / Br₂; HOAc / 1 h / 20 °C

4: 75 percent / aq. K₂CO₃; Pd(PPh₃)4 / toluene / 14 h / 90 °C

With sodium periodate; osmium(VIII) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrabutyl ammonium fluoride; bromine; potassium carbonate; acetic acid; In tetrahydrofuran; N,N-dimethyl-formamide; toluene; 4: Suzuki reaction;
DOI:10.1021/jm034041s

Reference yield:

: 85118-00-9
2,6-Difluorobenzyl bromide

: 552291-17-5
1-(2,6-difluorobenzyl)-3-(2-oxoethyl)-5-(3-methoxyphenyl)-6-methyluracil

Guidance literature:: Multi-step reaction with 4 steps

1: 59 percent / TBAF / tetrahydrofuran; dimethylformamide / 48 h / 20 °C

2: aq. NaIO₄; OsO₄ / tetrahydrofuran / 3 h / 20 °C

3: 1.1 g / Br₂; HOAc / 1 h / 20 °C

4: 75 percent / aq. K₂CO₃; Pd(PPh₃)4 / toluene / 14 h / 90 °C

With sodium periodate; osmium(VIII) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrabutyl ammonium fluoride; bromine; potassium carbonate; acetic acid; In tetrahydrofuran; N,N-dimethyl-formamide; toluene; 4: Suzuki reaction;
DOI:10.1021/jm034041s