C₃₄H₄₄O₁₂

Base Information

• Chemical Name: C₃₄H₄₄O₁₂
• CAS No.: 1018988-54-9
• Molecular Formula: C₃₄H₄₄O₁₂
• Molecular Weight: 644.716
• Mol file: 1018988-54-9.mol

Synonyms:C₃₄H₄₄O₁₂

Chemical Property of C₃₄H₄₄O₁₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₄H₄₄O₁₂

There total 19 articles about C₃₄H₄₄O₁₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

C35H48O13 (1018988-65-2) → C34H44O12 (1018988-54-9)

Guidance literature:

With sodium periodate; In ethanol; at 20 ℃; for 1h;

DOI:10.1002/anie.200704959

Reference yield: 75.0%

C34H46O12 (1018988-66-3) → C34H44O12 (1018988-54-9)

Guidance literature:

With Dess-Martin periodane; In dichloromethane; at 0 - 20 ℃;

DOI:10.1002/anie.200704959

Reference yield:

C52H66O7Si2 (1018988-59-4) → C34H44O12 (1018988-54-9)

Guidance literature:

Multi-step reaction with 16 steps

1.1: sodium tetrahydroborate / ethanol / 2 h / -78 °C / Inert atmosphere

2.1: dichloromethane / 1 h / 20 °C / Inert atmosphere; Molecular sieve

2.2: 39 h / 20 °C / Inert atmosphere

3.1: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

4.1: 2,6-di-tert-butyl-4-methylpyridine; 2,3-dicyano-5,6-dichloro-p-benzoquinone / acetonitrile / 20 °C / Inert atmosphere

5.1: sodium tetrahydroborate / tetrahydrofuran; ethanol / -40 - -30 °C / Inert atmosphere

6.1: sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid / dichloromethane / 24 h / 13 °C / Inert atmosphere

7.1: lithium borohydride / tetrahydrofuran / Inert atmosphere; Reflux

7.2: 4 h / 20 °C / Inert atmosphere

8.1: lithium borohydride / tetrahydrofuran / 26.5 h / 20 °C / Inert atmosphere; Reflux

8.2: 4 h / 20 °C / Inert atmosphere

9.1: water; acetic acid / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

10.1: dmap / pyridine; dichloromethane / 24 h / 20 °C / Inert atmosphere

11.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

12.1: peracetic acid; mercury(II) diacetate; acetic acid / 4 h / 20 °C / Inert atmosphere

13.1: 1H-imidazole / dichloromethane / 4 h / 0 °C / Inert atmosphere

14.1: dmap / pyridine; dichloromethane / 0 - 40 °C / Inert atmosphere

15.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 0 °C / Inert atmosphere

16.1: Dess-Martin periodane / dichloromethane / 0 - 20 °C / Inert atmosphere

With 1H-imidazole; peracetic acid; dmap; sodium tetrahydroborate; lithium borohydride; 2,6-di-tert-butyl-4-methylpyridine; mercury(II) diacetate; tetrabutyl ammonium fluoride; water; sodium hydrogencarbonate; Dess-Martin periodane; acetic acid; triethylamine; 3-chloro-benzenecarboperoxoic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; pyridine; ethanol; dichloromethane; acetonitrile; 5.1: Luche reduction / 12.1: Tamao oxidation;

DOI:10.1002/asia.200800429

upstream raw materials:

C₃₅H₄₈O₁₃

C₃₄H₄₆O₁₂

C₅₂H₆₆O₇Si₂

C₅₂H₆₈O₇Si₂

Downstream raw materials:

C₃₄H₄₆O₁₂

C₁₇H₂₀(OH)2(OCOCH₃)2(CH₂OCOCH₃)(CH₃)(OCOC₆H₄OCH₃)(CHCH₂)

C₅₀H₆₄O₁₂Si

C₃₇H₄₆O₁₃

Refernces

• 1、 Zhang, Hongxing,Sridhar Reddy, Maddi,Phoenix, Serge,Deslongchamps, Pierre. "Total synthesis of ouabagenin and ouabain". . p. 1272 - 1275. Retrieved 2008/12/22.