Technology Process of N1,N1,N3,N3-pentabenzylpropane-1,3-diamine
There total 4 articles about N1,N1,N3,N3-pentabenzylpropane-1,3-diamine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
ammonia; sodium;
In
tetrahydrofuran;
at -78 ℃;
for 1.5h;
Schlenk technique;
Inert atmosphere;
DOI:10.1002/anie.201403774
- Guidance literature:
-
Multi-step reaction with 4 steps
1: N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide / water / 2 h / 50 - 60 °C / Inert atmosphere
2: ethylmagnesium bromide / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere; Schlenk technique
3: Pd[(Xantphos)(CH3CN)2](OTf)2 / toluene / 12 h / 120 °C / Schlenk technique
4: ammonia; sodium / tetrahydrofuran / 1.5 h / -78 °C / Schlenk technique; Inert atmosphere
With
Pd[(Xantphos)(CH3CN)2](OTf)2; ethylmagnesium bromide; N-benzyl-N,N,N-triethylammonium chloride; ammonia; sodium; sodium hydroxide;
In
tetrahydrofuran; water; toluene;
DOI:10.1002/anie.201403774
- Guidance literature:
-
Multi-step reaction with 3 steps
1: ethylmagnesium bromide / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere; Schlenk technique
2: Pd[(Xantphos)(CH3CN)2](OTf)2 / toluene / 12 h / 120 °C / Schlenk technique
3: ammonia; sodium / tetrahydrofuran / 1.5 h / -78 °C / Schlenk technique; Inert atmosphere
With
Pd[(Xantphos)(CH3CN)2](OTf)2; ethylmagnesium bromide; ammonia; sodium;
In
tetrahydrofuran; toluene;
DOI:10.1002/anie.201403774
